Abstract
A new family of non-ionic amphiphilic dendro-calix[4]arene bearing hydrophilic branched substituents at the upper rim and lipophilic alkyl chains at the lower rim was designed and synthesized. Micelles of various sizes are obtained due to the amphiphilic nature of the calix[4]arene derivatives in aqueous medium. The amphiphilic calix[4]arene derivatives effectively load hydrophobic dye such as alizarin yellow via secondary interactions such as hydrogen bonding and π-π stacking. The length of alkyl chain and the intrinsic cyclic nature of calixarene scaffold have shown a significant impact on the transport potential of all amphiphiles.
Keywords: Calix[4]arene, Self-assembly, Micelles, Encapsulation potential
Current Organic Chemistry
Title:Design, Synthesis, and Transport Potential of a New Family of Nonionic Amphiphilic Dendro-calix[4]arene
Volume: 16 Issue: 22
Author(s): Khalid Khan, Hong Huang and Yan-Song Zheng
Affiliation:
Keywords: Calix[4]arene, Self-assembly, Micelles, Encapsulation potential
Abstract: A new family of non-ionic amphiphilic dendro-calix[4]arene bearing hydrophilic branched substituents at the upper rim and lipophilic alkyl chains at the lower rim was designed and synthesized. Micelles of various sizes are obtained due to the amphiphilic nature of the calix[4]arene derivatives in aqueous medium. The amphiphilic calix[4]arene derivatives effectively load hydrophobic dye such as alizarin yellow via secondary interactions such as hydrogen bonding and π-π stacking. The length of alkyl chain and the intrinsic cyclic nature of calixarene scaffold have shown a significant impact on the transport potential of all amphiphiles.
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Cite this article as:
Khan Khalid, Huang Hong and Zheng Yan-Song, Design, Synthesis, and Transport Potential of a New Family of Nonionic Amphiphilic Dendro-calix[4]arene, Current Organic Chemistry 2012; 16 (22) . https://dx.doi.org/10.2174/138527212804004562
DOI https://dx.doi.org/10.2174/138527212804004562 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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