Abstract
Research on steroid biooxidation is being pursued for development of processes exploitable by the pharmaceutical industry, and also for the purpose of preparation of potentially useful steroid analogues which are otherwise inaccessible. The use of enzymes provides high regio- and stereoselectivity of the reaction to be performed. In this work a review of recent and important findings related to microbial and enzymatic biotransformations of steroidal compounds including hydroxylation, Baeyer-Villiger oxidation, dehydrogenation and sterol side-chain cleavage is presented, with emphasis on processes of practical biotechnological importance. Although some of these bioconversions are well-established, efforts are ongoing in order to increase their efficiency as well as to discover novel steroidal compounds and acquire recombinant microorganisms capable of performing desired steroid biotransformations.
Keywords: Baeyer-Villiger Oxidation, Biotransformation of Steroids, Dehydrogenation, Microbial Transformation, Stereoselective Hydroxylation, Sterol Side-Chain Cleavage
Current Organic Chemistry
Title:Selective Modifications of Steroids Performed by Oxidative Enzymes
Volume: 16 Issue: 21
Author(s): Alina Swizdor, Teresa Kolek, Anna Panek and Natalia Milecka
Affiliation:
Keywords: Baeyer-Villiger Oxidation, Biotransformation of Steroids, Dehydrogenation, Microbial Transformation, Stereoselective Hydroxylation, Sterol Side-Chain Cleavage
Abstract: Research on steroid biooxidation is being pursued for development of processes exploitable by the pharmaceutical industry, and also for the purpose of preparation of potentially useful steroid analogues which are otherwise inaccessible. The use of enzymes provides high regio- and stereoselectivity of the reaction to be performed. In this work a review of recent and important findings related to microbial and enzymatic biotransformations of steroidal compounds including hydroxylation, Baeyer-Villiger oxidation, dehydrogenation and sterol side-chain cleavage is presented, with emphasis on processes of practical biotechnological importance. Although some of these bioconversions are well-established, efforts are ongoing in order to increase their efficiency as well as to discover novel steroidal compounds and acquire recombinant microorganisms capable of performing desired steroid biotransformations.
Export Options
About this article
Cite this article as:
Swizdor Alina, Kolek Teresa, Panek Anna and Milecka Natalia, Selective Modifications of Steroids Performed by Oxidative Enzymes, Current Organic Chemistry 2012; 16 (21) . https://dx.doi.org/10.2174/138527212804004625
DOI https://dx.doi.org/10.2174/138527212804004625 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Advances in Whole Genome Sequencing Technology
Current Pharmaceutical Biotechnology Fibrinogen, Fibrin, and Fibrin Degradation Products in COVID-19
Current Drug Targets Advances in Mycobacterium tuberculosis Structural Genomics: Investigating Potential Chinks in the Armor of a Deadly Pathogen
Infectious Disorders - Drug Targets Therapeutic Outlook of Pyrazole Analogs: A Mini Review
Mini-Reviews in Medicinal Chemistry Endocannabinoids as Regulators of Transient Receptor Potential (TRP)Channels: a Further Opportunity to Develop New Endocannabinoid-Based Therapeutic Drugs
Current Medicinal Chemistry Cysteine and Selenocysteine Deprotection Chemistry in Peptide Synthesis
Mini-Reviews in Organic Chemistry Implications of Photophysical and Physicochemical Factors on Successful Application of Photodynamic Therapy
Current Pharmaceutical Design Current Overview on the Usage of Poly(ADP-ribose)polymerase (PARP) Inhibitors in Treating Cancer
Clinical Cancer Drugs A Collaborative Hit-to-Lead Investigation Leveraging Medicinal Chemistry Expertise with High Throughput Library Design, Synthesis and Purification Capabilities
Combinatorial Chemistry & High Throughput Screening Long-Haul COVID-19: Imaging or Functional Testing?
Current Respiratory Medicine Reviews Gram-scale Synthesis of a Novel Core Building Block for the New GPR40 Agonist Design
Letters in Organic Chemistry Exploring Newer Target Sodium Glucose Transporter 2 for the Treatment of Diabetes Mellitus
Mini-Reviews in Medicinal Chemistry Patent Review
Combinatorial Chemistry & High Throughput Screening Ligand- and Protein-Based Modeling Studies of the Inhibitors of Human Cytochrome P450 2D6 and a Virtual Screening for Potential Inhibitors from the Chinese Herbal Medicine, Scutellaria baicalensis (Huangqin,Baikal Skullcap)
Combinatorial Chemistry & High Throughput Screening Carbonic Anhydrase Inhibition/Activation: Trip of a Scientist Around the World in the Search of Novel Chemotypes and Drug Targets
Current Pharmaceutical Design Generating a Biological Pacemaker - Tackling Arrhythmias the Stem Cell Way
Recent Patents on Regenerative Medicine Correlations and Hierarchical Clustering Investigation Between Weather and SARS-CoV-2
Recent Advances in Computer Science and Communications Diabetic Theory in Anti-Alzheimer’s Drug Research and Development. Part 2: Therapeutic Potential of cAMP-Specific Phosphodiesterase Inhibitors
Current Medicinal Chemistry Medicinal Chemistry Strategies to Minimize Phospholipidosis
Current Medicinal Chemistry Dual Ligands Targeting Dopamine D2 and Serotonin 5-HT<sub>1A</sub> Receptors as New Antipsychotical or Anti-Parkinsonian Agents
Current Medicinal Chemistry