Abstract
Plague is an infectious disease with a high mortality rate that has repeatedly impacted human society. It remains a threat in many parts of the world today. Plague is caused by the bacterium, Yersinia pestis (Y. pestis), which has as one of its required virulence factors, the protein-tyrosine phosphatase, YopH. Therefore, YopH represents a potential target for the treatment of Y. pestis infection. Recent recognition of Y. pestis as a possible bioterrorism agent and the fact that it is still the cause of endemic disease around the world make it an important object of study and heighten the need for new anti-plague agents. The current review covers aspects of plague and its historical occurrence and summarizes approaches to developing YopH inhibitors.
Keywords: Inhibitors, plague, protein-tyrosine phosphatase (PTP), Yersinia pestis, YopH, TTSS, P-loop, WPD-loop, EGFR, F2Pmp
Current Medicinal Chemistry
Title:Yersinia pestis and Approaches to Targeting its Outer Protein H Protein-Tyrosine Phosphatase (YopH)
Volume: 19 Issue: 33
Author(s): M. Bahta and T.R. Burke
Affiliation:
Keywords: Inhibitors, plague, protein-tyrosine phosphatase (PTP), Yersinia pestis, YopH, TTSS, P-loop, WPD-loop, EGFR, F2Pmp
Abstract: Plague is an infectious disease with a high mortality rate that has repeatedly impacted human society. It remains a threat in many parts of the world today. Plague is caused by the bacterium, Yersinia pestis (Y. pestis), which has as one of its required virulence factors, the protein-tyrosine phosphatase, YopH. Therefore, YopH represents a potential target for the treatment of Y. pestis infection. Recent recognition of Y. pestis as a possible bioterrorism agent and the fact that it is still the cause of endemic disease around the world make it an important object of study and heighten the need for new anti-plague agents. The current review covers aspects of plague and its historical occurrence and summarizes approaches to developing YopH inhibitors.
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Cite this article as:
Bahta M. and Burke T.R., Yersinia pestis and Approaches to Targeting its Outer Protein H Protein-Tyrosine Phosphatase (YopH), Current Medicinal Chemistry 2012; 19 (33) . https://dx.doi.org/10.2174/092986712803988866
DOI https://dx.doi.org/10.2174/092986712803988866 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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