Plague is an infectious disease with a high mortality rate that has repeatedly impacted human society. It remains a threat in
many parts of the world today. Plague is caused by the bacterium, Yersinia pestis (Y. pestis), which has as one of its required virulence
factors, the protein-tyrosine phosphatase, YopH. Therefore, YopH represents a potential target for the treatment of Y. pestis infection.
Recent recognition of Y. pestis as a possible bioterrorism agent and the fact that it is still the cause of endemic disease around the world
make it an important object of study and heighten the need for new anti-plague agents. The current review covers aspects of plague and
its historical occurrence and summarizes approaches to developing YopH inhibitors.
Keywords: Inhibitors, plague, protein-tyrosine phosphatase (PTP), Yersinia pestis, YopH, TTSS, P-loop, WPD-loop, EGFR, F2Pmp
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