Cocaine belongs to the group of psychostimulants and together with amphetamines has been recognized as one of the most
significant examples of drug abuse. Cocaine abuse is due to intense feelings of euphoria, friendliness, empathy, and hyperactivity, which
result from its potent inhibitory effects on presynaptic dopamine and noradrenaline re-uptake. Misuse of cocaine can induce severe toxic
effects, including neurotoxicity, cardiotoxicity, hepatotoxicity. There are a number of data, both experimental and clinical, regarding its
hepatotoxic effects, associated with lipid peroxidation-induced oxidative damage. The oxidative metabolism of cocaine to reactive oxygen
species (ROS) like nitrogen peroxide and superoxide anion radicals are thought to be responsible for the cocaine associated liver injury.
This review summarizes the present information on cocaine hepatic biotransformation and the possible role of its oxidative metabolism
in cocaine-induced hepatic injury.
Keywords: Cocaine hepatotoxicity, oxidative stress, lipid peroxidation, antioxidant defence, psychostimulants, amphetamines, drug abuse, Cocaine abuse, intense feelings of euphoria, hyperactivity
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