Abstract
Although some myokines exert their actions on other organs in a hormone–like fashion, many of them operate locally on skeletal muscle themselves. Myokines may thereby provide a feedback loop for the muscle to regulate its own growth and regeneration allowing for adaptation to exercise training. The myokine concept provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs within the muscle itself. New biotechnological patents are published based on the identification of new myokines, and these myokines and their receptors will potentially serve as pharmacological targets for treating muscle diseases, metabolic disorders and other diseases associated with muscle disuse.
Keywords: Skeletal muscle, exercise, metabolism, metabolic diseases, activity, inactivity, muscle, muscle cells, myoblasts, myocytes, myogenesis, cytokines, myokines, interleukins, IL-6, irisin, muscle wasting, muscular dystrophies, sarcopenia, patents
Recent Patents on Biotechnology
Title:Myokines in Myogenesis and Health
Volume: 6 Issue: 3
Author(s): Tora Henriksen, Charlotte Green and Bente Klarlund Pedersen
Affiliation:
Keywords: Skeletal muscle, exercise, metabolism, metabolic diseases, activity, inactivity, muscle, muscle cells, myoblasts, myocytes, myogenesis, cytokines, myokines, interleukins, IL-6, irisin, muscle wasting, muscular dystrophies, sarcopenia, patents
Abstract: Although some myokines exert their actions on other organs in a hormone–like fashion, many of them operate locally on skeletal muscle themselves. Myokines may thereby provide a feedback loop for the muscle to regulate its own growth and regeneration allowing for adaptation to exercise training. The myokine concept provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs within the muscle itself. New biotechnological patents are published based on the identification of new myokines, and these myokines and their receptors will potentially serve as pharmacological targets for treating muscle diseases, metabolic disorders and other diseases associated with muscle disuse.
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Cite this article as:
Henriksen Tora, Green Charlotte and Klarlund Pedersen Bente, Myokines in Myogenesis and Health, Recent Patents on Biotechnology 2012; 6 (3) . https://dx.doi.org/10.2174/1872208311206030167
DOI https://dx.doi.org/10.2174/1872208311206030167 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
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