Abstract
Mimics of oligosaccharides capable of interfering with lectin activity are currently being pursued by a number of groups in an effort to produce tools for glycobiology and to design antagonists of medically relevant lectins. The field is reviewed in this chapter. After a brief overview of the state of the art, examples from our and others’ studies on the dendritic cell receptor DC-SIGN are illustrated.
Keywords: Carbohydrates, glycomimetics, C-type lectins and DC-SIGN, Pseudomonas aeruginosa, LECTINS, carbohydrate-encoded, high-mannose, oligosaccharides
Mini-Reviews in Medicinal Chemistry
Title:Carbohydrate Mimics and Lectins: A Source of New Drugs and Therapeutic Opportunities
Volume: 12 Issue: 14
Author(s): Jose J. Reina and Anna Bernardi
Affiliation:
Keywords: Carbohydrates, glycomimetics, C-type lectins and DC-SIGN, Pseudomonas aeruginosa, LECTINS, carbohydrate-encoded, high-mannose, oligosaccharides
Abstract: Mimics of oligosaccharides capable of interfering with lectin activity are currently being pursued by a number of groups in an effort to produce tools for glycobiology and to design antagonists of medically relevant lectins. The field is reviewed in this chapter. After a brief overview of the state of the art, examples from our and others’ studies on the dendritic cell receptor DC-SIGN are illustrated.
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Cite this article as:
J. Reina Jose and Bernardi Anna, Carbohydrate Mimics and Lectins: A Source of New Drugs and Therapeutic Opportunities, Mini-Reviews in Medicinal Chemistry 2012; 12 (14) . https://dx.doi.org/10.2174/138955712803832690
DOI https://dx.doi.org/10.2174/138955712803832690 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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