Abstract
The effect of extraction solvents (methanol, 95%ethanol, and water) on total phenolic contents and free radical scavenging activity (FRSA) of Gynura procumbens leaf was investigated. The contents of total phenolic and in vitro FRSA were significantly higher in the methanol extract compared to the 95% ethanol and water extracts. Consequently, the effect of the methanol extract on plasma lipid peroxidation and plasma total antioxidant status in carbon tetrachloride (CCl4) -induced oxidative stress in rats was determined. The administration of CCl4 to rats showed significant increase in plasma thiobarbituric acid reactive substances (TBARS) levels. The plasma lipid peroxidation elevation produced by CCl4 was reversed in rats fed with the methanol extract of G. procumbens leaf for 14 days before CCl4 challenge. Administration of CCl4 to rats did not showed significant alteration in plasma total antioxidant status (TAS).
Keywords: Antioxidant, extraction solvents, Gynura procumbens, lipid peroxidation, plasma, plant, substances, antioxidant, lipid, leaf.
The Natural Products Journal
Title:Effects of Gynura procumbens Leaf Extracts on Plasma Lipid Peroxidation and Total Antioxidant Status in CCl4-Treated Rats
Volume: 2 Issue: 4
Author(s): Gabriel A. Akowuah, Mariam Ahmad and Yam M. Fei
Affiliation:
Keywords: Antioxidant, extraction solvents, Gynura procumbens, lipid peroxidation, plasma, plant, substances, antioxidant, lipid, leaf.
Abstract: The effect of extraction solvents (methanol, 95%ethanol, and water) on total phenolic contents and free radical scavenging activity (FRSA) of Gynura procumbens leaf was investigated. The contents of total phenolic and in vitro FRSA were significantly higher in the methanol extract compared to the 95% ethanol and water extracts. Consequently, the effect of the methanol extract on plasma lipid peroxidation and plasma total antioxidant status in carbon tetrachloride (CCl4) -induced oxidative stress in rats was determined. The administration of CCl4 to rats showed significant increase in plasma thiobarbituric acid reactive substances (TBARS) levels. The plasma lipid peroxidation elevation produced by CCl4 was reversed in rats fed with the methanol extract of G. procumbens leaf for 14 days before CCl4 challenge. Administration of CCl4 to rats did not showed significant alteration in plasma total antioxidant status (TAS).
Export Options
About this article
Cite this article as:
A. Akowuah Gabriel, Ahmad Mariam and M. Fei Yam, Effects of Gynura procumbens Leaf Extracts on Plasma Lipid Peroxidation and Total Antioxidant Status in CCl4-Treated Rats, The Natural Products Journal 2012; 2 (4) . https://dx.doi.org/10.2174/2210315511202040247
DOI https://dx.doi.org/10.2174/2210315511202040247 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
Call for Papers in Thematic Issues
Ayurvedic medicinal therapeutic approaches for inflammatory and neurodegenerative disorders
Usually, in our elderly population, neurodegenerative disorders occur due to neuron death. Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disease. Dementia is the leading cause of AD, which affects about 30 million people worldwide. According to the World Alzheimer report 2018, a new case of dementia develops every ...read more
Recent Advances in Biotransformation of Bioactive Terpenoids using Aspergillus niger
Biotransformation is the reaction catalyzed by biological catalysts of either isolated enzymes or whole cell cultures of microorganisms. This process has been extensively applied in the conversion of bioactive terpenoids with high regio- and stereospecifity. This process has been also applied in the lead discovery and development. Aspergillus niger has ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Novel Insights into Vascular Repair Mechanisms
Current Pharmaceutical Design Granulocyte Colony-Stimulating Factor Attenuates Blood-Brain Barrier Damage and Improves Cognitive Function in Spontaneously Hypertensive Rats
CNS & Neurological Disorders - Drug Targets Nanostructures for Drug Delivery to the Brain
Current Medicinal Chemistry Impact of Guidelines on Hypertension Control in the Elderly
Current Pharmaceutical Design The Frequency of Thrombotic Events Among Adults Given Antifibrinolytic Drugs for Spontaneous Bleeding: Systematic Review and Meta-Analysis of Observational Studies and Randomized Trials
Current Drug Safety The Impact of Metabolic Disease Associated with Metabolic Syndrome on Human Pregnancy
Current Pharmaceutical Biotechnology General Aspects of Metal Toxicity
Current Medicinal Chemistry A Brief Review of Blue- and Bilberries’ Potential to Curb Cardio-Metabolic Perturbations: Focus on Diabetes
Current Pharmaceutical Design Cardiac Remodeling Induced by Smoking: Concepts, Relevance, and Potential Mechanisms
Inflammation & Allergy - Drug Targets (Discontinued) Pathogenesis of the Podocytopathy and Proteinuria in Diabetic Glomerulopathy
Current Diabetes Reviews Cardioembolic Stroke: Clinical Features, Specific Cardiac Disorders and Prognosis
Current Cardiology Reviews Chronic Kidney Disease and the Risk of Cardiovascular Disease Events: A Community-Based Approach
Vascular Disease Prevention (Discontinued) L-Arginine in the Prevention and Treatment of Cardiovascular Disease: From Basic to Clinical Research Studies
Vascular Disease Prevention (Discontinued) Role of Adiponectin in the Metabolic Syndrome: Current Perspectives on its Modulation as a Treatment Strategy
Current Pharmaceutical Design Surfactant Replacement Therapy in Pediatric Acute Lung Injury/Acute Respiratory Distress Syndrome
Current Respiratory Medicine Reviews Sepsis-induced Cardiomyopathy
Current Cardiology Reviews Insulin, Thrombin, ERK1/2 Kinase and Vascular Smooth Muscle Cells Proliferation
Current Pharmaceutical Design Seasonal Allergic Rhinitis
Recent Patents on Inflammation & Allergy Drug Discovery Cardiovascular Effects of Endogenous Estrogen and Hormone Therapy
Current Vascular Pharmacology Polymorphism of UDP-Glucuronosyltransferase and Drug Metabolism
Current Drug Metabolism