Abstract
Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-associated molecular patterns, are critical for the normal function of the innate immune system. Following their discovery many single nucleotide polymorphisms within TLRs and components of their signaling machinery have been discovered and subsequently implicated in a wide range of human diseases including atherosclerosis, sepsis, asthma, and immunodeficiency. This review discusses the effect of genetic variation on TLR function and how they may precipitate disease.
Keywords: Atherosclerosis, Genetic association studies, Inflammation, Innate immunity, Single nucleotide polymorphisms, Toll-like receptors, sepsis, immunodeficiency, polymorphisms, Caenorhadbitis elegans.
Current Genomics
Title:Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
Volume: 13 Issue: 8
Author(s): Yi-Tzu Lin, Amanda Verma and Conrad P. Hodgkinson
Affiliation:
Keywords: Atherosclerosis, Genetic association studies, Inflammation, Innate immunity, Single nucleotide polymorphisms, Toll-like receptors, sepsis, immunodeficiency, polymorphisms, Caenorhadbitis elegans.
Abstract: Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-associated molecular patterns, are critical for the normal function of the innate immune system. Following their discovery many single nucleotide polymorphisms within TLRs and components of their signaling machinery have been discovered and subsequently implicated in a wide range of human diseases including atherosclerosis, sepsis, asthma, and immunodeficiency. This review discusses the effect of genetic variation on TLR function and how they may precipitate disease.
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Cite this article as:
Lin Yi-Tzu, Verma Amanda and P. Hodgkinson Conrad, Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms, Current Genomics 2012; 13 (8) . https://dx.doi.org/10.2174/138920212803759712
DOI https://dx.doi.org/10.2174/138920212803759712 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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