Targeting Pathways Contributing to Epithelial-Mesenchymal Transition (EMT) in Epithelial Ovarian Cancer

Ruby      Yun-Ju Huang; Vin      Yee Chung; Jean      Paul Thiery

Abstract

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Discovery of novel therapeutic opportunities for EOC is important for the improvement of clinical outcome of the patients. Emerging evidence is suggesting that epithelial-mesenchymal transition (EMT) plays a crucial role in the aggressiveness in EOC including increasing migration and invasion ability, contributing to chemoresistance and cancer stem cell populations. Targeting EMT in EOC thus offers an attractive therapeutic option.

Keywords: Epithelial-mesenchymal transition, ovarian cancer, Epithelial-mesenchymal transition, ovarian cancer, chemoresistance, motile mesenchymal cells, cnidarian species, embryonic epithelia, Drosophila embryos, Twist, Snail, tumor cells

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Current Drug Targets

Title:Targeting Pathways Contributing to Epithelial-Mesenchymal Transition (EMT) in Epithelial Ovarian Cancer

Volume: 13 Issue: 13

Author(s): Ruby Yun-Ju Huang, Vin Yee Chung and Jean Paul Thiery

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Abstract: Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Discovery of novel therapeutic opportunities for EOC is important for the improvement of clinical outcome of the patients. Emerging evidence is suggesting that epithelial-mesenchymal transition (EMT) plays a crucial role in the aggressiveness in EOC including increasing migration and invasion ability, contributing to chemoresistance and cancer stem cell populations. Targeting EMT in EOC thus offers an attractive therapeutic option.

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Yun-Ju Huang Ruby, Yee Chung Vin and Paul Thiery Jean, Targeting Pathways Contributing to Epithelial-Mesenchymal Transition (EMT) in Epithelial Ovarian Cancer, Current Drug Targets 2012; 13 (13) . https://dx.doi.org/10.2174/138945012803530044

DOI https://dx.doi.org/10.2174/138945012803530044	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592

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