Abstract
Opioid consumption is associated with a wide range of side effects. Potential interference of opioids with bone and joint activity has emerged in the last few years. Opioids increase the risk of fracture, especially in elderly patients. Moreover, opioids interfere with the endocrine system, and their chronic use is a recognized risk factor for osteoporosis. Pathogenetic mechanisms at the basis of the interference of opioids with bones and joints are analysed in this review.
Keywords: Opioid, bone, osteoporosis, endocrine, pain, fracture, joints, side effects, elderly patients, risk factor.
Current Pharmaceutical Design
Title:Non-Analgesic Effects of Opioids: The Interaction of Opioids with Bone and Joints
Volume: 18 Issue: 37
Author(s): Consalvo Mattia, Eleonora Di Bussolo and Flaminia Coluzzi
Affiliation:
Keywords: Opioid, bone, osteoporosis, endocrine, pain, fracture, joints, side effects, elderly patients, risk factor.
Abstract: Opioid consumption is associated with a wide range of side effects. Potential interference of opioids with bone and joint activity has emerged in the last few years. Opioids increase the risk of fracture, especially in elderly patients. Moreover, opioids interfere with the endocrine system, and their chronic use is a recognized risk factor for osteoporosis. Pathogenetic mechanisms at the basis of the interference of opioids with bones and joints are analysed in this review.
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Cite this article as:
Mattia Consalvo, Di Bussolo Eleonora and Coluzzi Flaminia, Non-Analgesic Effects of Opioids: The Interaction of Opioids with Bone and Joints, Current Pharmaceutical Design 2012; 18 (37) . https://dx.doi.org/10.2174/138161212803582487
DOI https://dx.doi.org/10.2174/138161212803582487 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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