Abstract
We recently showed that chitosan containing hydrogel isare capable of displaying antioxidant activity and prevents formation of oxidative DNA damage in vitro [9].
In this short communication we report our investigations towards developing two alternative novel simple flexible and effective drug delivery systems that provide optimal dosage of drugs precisely where and when needed and therefore achieve and sustain a complex delivery profile. Two topics of a. free radical generation in biocompatible media and b. supramolecular host-guest recognition through miniaturizing and multi-functionalizing molecular carriers for improved drug delivery in disease-specific manner are combined with the aim of harnessing free radical reactivity within the laboratory and developing alternative and effective treatments for disease states mediated by free radicals.
Keywords: Free radicals, chitosan, drug delivery systems, host-guest chemistry, aqueous media, cross-links, spectrophotometer, antioxidant efficiency, trichloroacetic acid.
Current Organic Chemistry
Title:Towards Development of Novel Chitosan Based Drug Delivery Prototypes: Devices for Targeted Delivery Drug Therapy at the Molecular Level in Aqueous Media
Volume: 16 Issue: 20
Author(s): Victoria T. Perchyonok, Shengmiao Zhang and Theunis Oberholzer
Affiliation:
Keywords: Free radicals, chitosan, drug delivery systems, host-guest chemistry, aqueous media, cross-links, spectrophotometer, antioxidant efficiency, trichloroacetic acid.
Abstract: We recently showed that chitosan containing hydrogel isare capable of displaying antioxidant activity and prevents formation of oxidative DNA damage in vitro [9].
In this short communication we report our investigations towards developing two alternative novel simple flexible and effective drug delivery systems that provide optimal dosage of drugs precisely where and when needed and therefore achieve and sustain a complex delivery profile. Two topics of a. free radical generation in biocompatible media and b. supramolecular host-guest recognition through miniaturizing and multi-functionalizing molecular carriers for improved drug delivery in disease-specific manner are combined with the aim of harnessing free radical reactivity within the laboratory and developing alternative and effective treatments for disease states mediated by free radicals.
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Cite this article as:
T. Perchyonok Victoria, Zhang Shengmiao and Oberholzer Theunis, Towards Development of Novel Chitosan Based Drug Delivery Prototypes: Devices for Targeted Delivery Drug Therapy at the Molecular Level in Aqueous Media, Current Organic Chemistry 2012; 16 (20) . https://dx.doi.org/10.2174/138527212803520155
DOI https://dx.doi.org/10.2174/138527212803520155 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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