Analysis Toward Innovative Herbal Antibacterial & Antifungal Drugs

Sandeep      Dhankhar; Seema      Dhankhar; Manish      Kumar; Sonam      Ruhil; Meenakshi      Balhara; Anil      K. Chhillar

Abstract

The antimicrobial activities of four medicinal plants Argemona mexicana, Achyranthes aspera, Catharanthus roseus, and Syzygium cumini were evaluated against Escherichia coli, Vibrio cholerae, Klebsiella pneumoniae, Proteus vulgaris, Bacillus subtilis, Salmonella typhi and three Aspergillus species. Extracts from Achyranthes aspera and Catharanthus roseus showed the highest antimicrobial potential (MIC 0.375-0.750 mg/ml) while extract from Argemona mexicana and Syzygium cumini, showed less activity. In disc diffusion assay, only eight out of twenty extracts showed antimicrobial activity at a concentration of 25.0 μg/ disc. The GCMS investigation reveals the existence of 2-bornanone; 1, 2-benzenedicarboxylic acid, bis (2-methylpropyl) ester; hexadecanoic acid, methyl ester and hexatriacontane in water extract fraction of C. roseus. The present research article provides a review of some medicinal plants incorporating antimicrobial drugs, together with recent advances in emerging therapeutics in clinical development and related patents for exploitation of herbal medicine.

Keywords: Antimicrobial, Aspergillus species, Catharanthus roseus, drugs, medicinal plants, patents, medicinal plants, Reference Strain, Bacterial Culture, Dilution Assay, Gas Chromatography Mass Spectrometric