An Efficient Ultrasound Promoted One-Pot Three-Component Synthesis and Antibacterial Activities of Novel Pyrimido[4,5-b]quinoline- 4,6(3H,5H,7H,10H)-dione Derivatives

Title:An Efficient Ultrasound Promoted One-Pot Three-Component Synthesis and Antibacterial Activities of Novel Pyrimido[4,5-b]quinoline- 4,6(3H,5H,7H,10H)-dione Derivatives

Volume: 9 Issue: 9

Author(s): Maryam S. Jourshari, Manouchehr Mamaghani, Khalil Tabatabaeian, Farhad Shirini, Mehdi Rassa and Hadiss Langhari

Affiliation:

Keywords: 6-aminothiouracil, antibacterial, MCR, one-pot, pyrimido[4, 5-b]quinolone, pyridopyrimidine, pyrazole, ultrasound, synthesis, yields

Abstract: A series of novel pyrimido[4,5-b]quinoline-4,6(3H,5H,7H,10H)-dione derivatives was synthesized by one-pot three-component reaction of the appropriate aldehyde, dimedone or cyclohexanedione and 6-aminothiouracil in ethanol under ultrasonic irradiation at 50 oC in short reaction times (1.5-3 min) and excellent yields (94-99%). The antibacterial activities of the synthesized compounds were evaluated on M. leuteus, B. subtilis, E. coli and Ps. aeruginosa. All the synthesized products showed good antibacterial activities.

Cite this article as:

S. Jourshari Maryam, Mamaghani Manouchehr, Tabatabaeian Khalil, Shirini Farhad, Rassa Mehdi and Langhari Hadiss, An Efficient Ultrasound Promoted One-Pot Three-Component Synthesis and Antibacterial Activities of Novel Pyrimido[4,5-b]quinoline- 4,6(3H,5H,7H,10H)-dione Derivatives, Letters in Organic Chemistry 2012; 9 (9) . https://dx.doi.org/10.2174/157017812803521207