Enantioselective Addition of Diethylzinc to Aldehydes by Chiral Oxazolidine–Titanium Complex

Title:Enantioselective Addition of Diethylzinc to Aldehydes by Chiral Oxazolidine–Titanium Complex

Volume: 9 Issue: 9

Author(s): Nan Wu, Rongcheng Bo, Rongli Zhang, Xi Jiang, Yu Wan, Zhou Xu and Hui Wu

Affiliation:

Keywords: Asymmetric alkynylation, enantioselectivity oxazolidine, secondary alcohol, Chiral, dialkylzinc reagents, schlenk tube, organic layer, UV detection, Aldrich, chelating group

Abstract: A series of chiral oxazolidines derived from (1R, 2S)-cis-1-amino-2-indanol was found to be effective in promoting the asymmetric addition of diethylzinc to aldehydes. Among the ligands developed, it was found that ligand 1b in the presence of Ti(OiPr)4 yielded the highest enantioselectivities when it was applied in the catalytic asymmetric addition of diethylzinc to aldehydes (up to 91% ee).

Cite this article as:

Wu Nan, Bo Rongcheng, Zhang Rongli, Jiang Xi, Wan Yu, Xu Zhou and Wu Hui, Enantioselective Addition of Diethylzinc to Aldehydes by Chiral Oxazolidine–Titanium Complex, Letters in Organic Chemistry 2012; 9 (9) . https://dx.doi.org/10.2174/157017812803521180