Abstract
Celiac disease is a multi-systemic autoimmune disease of the small bowel induced by gluten in genetically predisposed subjects. Highly specific and gluten-dependent production of auto-antibodies targeting self-proteins of the transglutaminase family occurs in the intestinal mucosa. These anti-transglutaminase antibodies are found deposited in intestinal and extra-intestinal tissue where they might exert biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. We conducted a brief review on antitransglutaminase antibodies effects, discussing their roles in the pathogenesis of several clinical manifestations of celiac disease.
Keywords: Genetic gluten intolerance, intestinal anti-transglutaminase antibodies, auto-immunity
Current Pharmaceutical Design
Title:Gluten-dependent Intestinal Autoimmune Response
Volume: 18 Issue: 35
Author(s): Ilma Rita Korponay-Szabo, Zsofia Simon-Vecsei, Luigina De Leo and Tarcisio Not
Affiliation:
Keywords: Genetic gluten intolerance, intestinal anti-transglutaminase antibodies, auto-immunity
Abstract: Celiac disease is a multi-systemic autoimmune disease of the small bowel induced by gluten in genetically predisposed subjects. Highly specific and gluten-dependent production of auto-antibodies targeting self-proteins of the transglutaminase family occurs in the intestinal mucosa. These anti-transglutaminase antibodies are found deposited in intestinal and extra-intestinal tissue where they might exert biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. We conducted a brief review on antitransglutaminase antibodies effects, discussing their roles in the pathogenesis of several clinical manifestations of celiac disease.
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Cite this article as:
Rita Korponay-Szabo Ilma, Simon-Vecsei Zsofia, De Leo Luigina and Not Tarcisio, Gluten-dependent Intestinal Autoimmune Response, Current Pharmaceutical Design 2012; 18 (35) . https://dx.doi.org/10.2174/138161212803530826
DOI https://dx.doi.org/10.2174/138161212803530826 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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