Abstract
The present study is aimed at improving the dissolution of poorly soluble drug, rofecoxib, using solid dispersion technique. The solid dispersions were prepared in different proportions using hydrophilic carriers like mannitol, and urea. The dissolution rate studies were performed in both simulated gastric fluid and simulated intestinal fluid. It is observed that the dissolution was affected by the acidity of the medium. Solid dispersions gave faster dissolution rate when compared to corresponding physical mixture and pure drug. In vivo absorption and anti-inflammatory activity studies of solid dispersions also confirmed the above results. The DSC thermogram and IR spectra revealed that there is no interaction of Rofecoxib with additives and the drug, rofecoxib is stable in solid dispersions.
Keywords: Rofecoxib, solid dispersions, urea, mannitol, gastric fluid, physical mixture, anti-inflammatory, solid dispersions, Differential scanning calorimetric, Infrared.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:Preparation and Characterization of Solid Dispersions of Rofecoxib
Volume: 10 Issue: 6
Author(s): M. V. Ramana, Kamal Dua, M. Himaja and Kavita Pabreja
Affiliation:
Keywords: Rofecoxib, solid dispersions, urea, mannitol, gastric fluid, physical mixture, anti-inflammatory, solid dispersions, Differential scanning calorimetric, Infrared.
Abstract: The present study is aimed at improving the dissolution of poorly soluble drug, rofecoxib, using solid dispersion technique. The solid dispersions were prepared in different proportions using hydrophilic carriers like mannitol, and urea. The dissolution rate studies were performed in both simulated gastric fluid and simulated intestinal fluid. It is observed that the dissolution was affected by the acidity of the medium. Solid dispersions gave faster dissolution rate when compared to corresponding physical mixture and pure drug. In vivo absorption and anti-inflammatory activity studies of solid dispersions also confirmed the above results. The DSC thermogram and IR spectra revealed that there is no interaction of Rofecoxib with additives and the drug, rofecoxib is stable in solid dispersions.
Export Options
About this article
Cite this article as:
V. Ramana M., Dua Kamal, Himaja M. and Pabreja Kavita, Preparation and Characterization of Solid Dispersions of Rofecoxib, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2011; 10 (6) . https://dx.doi.org/10.2174/1871523011109060393
DOI https://dx.doi.org/10.2174/1871523011109060393 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Use of Citrullinated Peptides for the Diagnosis and Prognosis of Rheumatoid Arthritis
Current Topics in Medicinal Chemistry Genetics in Osteoarthritis
Current Genomics Gene Delivery for Cancer Therapy
Current Drug Delivery In Silico Approaches to the Design of NS5A Inhibitors
Current Topics in Medicinal Chemistry CAM Use in Pediatric Oncology
Current Pediatric Reviews Fluorescein Fluorescence Use in the Management of Intracranial Neoplastic and Vascular Lesions: A Review and Report of a New Technique
Current Drug Discovery Technologies New Insights into Chemistry and Anti-Infective Potential of Triazole Scaffold
Current Medicinal Chemistry Resolving Inflammation in Heart Failure: Novel Protective Lipid Mediators
Current Drug Targets A Review of Eugenol-based Nanomedicine: Recent Advancements
Current Bioactive Compounds Editorial: Inflammasomes – In Health and Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Donkey and Goat Milk Intake and Modulation of the Human Aged Immune Response
Current Pharmaceutical Design Redox Mechanisms of Vascular Cell Dysfunction in Sepsis
Endocrine, Metabolic & Immune Disorders - Drug Targets Trends in the Exploration of Anticancer Targets and Strategies in Enhancing the Efficacy of Drug Targeting
Current Molecular Pharmacology Unraveling Progesterone-Induced Molecular Mechanisms in Physiological and Pathological Conditions
Current Clinical Pharmacology Plant Polysaccharides with Immunostimulatory Activities
Current Organic Chemistry Pharmacologic Therapy for Cardiovascular Risk Reduction in Patients with the Metabolic Syndrome
Current Pharmaceutical Design Nutritional and therapeutic approaches to modulate NADPH oxidase-derived ROS signaling in platelets.
Current Pharmaceutical Design Autosomal Dominant Hypercholesterolemia: Needs for Early Diagnosis and Cascade Screening in the Tunisian Population
Current Genomics Strong Association of Serum GSK-3β/BDNF Ratio with Mild Cognitive Impairment in Elderly Type 2 Diabetic Patients
Current Alzheimer Research A Review on Structurally Diversified Synthesized Molecules as Monoacylglycerol Lipase Inhibitors and their Therapeutic uses
Current Drug Research Reviews