Abstract
Malignant glioma remains a disease with poor prognosis despite recent advances in the multidisciplinary care of this disease. Herein we review the evolution of and recent advances in radiation therapy for malignant glioma that have allowed for more targeted therapy, potentially improving efficacy while decreasing normal tissue toxicity. Current and emerging techniques are presented, including stereotactic radiotherapy and radiosurgery, brachytherapy, radioimmunotherapy, and charged particle therapy, as well as the combination of these modalities with novel targeted biochemotherapies.
Keywords: Brachytherapy, charged particle therapy, glioma, radiotherapy, radiosurgery, radioimmunotherapy, biochemotherapies, Glioblastoma multiforme (GBM), radiosensitizers, CT scans
Current Drug Discovery Technologies
Title:Targeted Radiotherapy for Malignant Gliomas
Volume: 9 Issue: 4
Author(s): Daniel S. Oh, David C. Adamson and John P. Kirkpatrick
Affiliation:
Keywords: Brachytherapy, charged particle therapy, glioma, radiotherapy, radiosurgery, radioimmunotherapy, biochemotherapies, Glioblastoma multiforme (GBM), radiosensitizers, CT scans
Abstract: Malignant glioma remains a disease with poor prognosis despite recent advances in the multidisciplinary care of this disease. Herein we review the evolution of and recent advances in radiation therapy for malignant glioma that have allowed for more targeted therapy, potentially improving efficacy while decreasing normal tissue toxicity. Current and emerging techniques are presented, including stereotactic radiotherapy and radiosurgery, brachytherapy, radioimmunotherapy, and charged particle therapy, as well as the combination of these modalities with novel targeted biochemotherapies.
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Cite this article as:
S. Oh Daniel, C. Adamson David and P. Kirkpatrick John, Targeted Radiotherapy for Malignant Gliomas, Current Drug Discovery Technologies 2012; 9 (4) . https://dx.doi.org/10.2174/157016312803305870
DOI https://dx.doi.org/10.2174/157016312803305870 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
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