Abstract
Aging can be defined as a process of progressive decline in the physiological capacity of an organism, manifested by accumulated alteration and destabilization at the whole system level. Systems biology approaches offer a promising new perspective to examine the old problem of aging. We begin this review by introducing the concepts of systems biology, and then illustrate the application of systems biology approaches to aging research, from gene expression profiling to network analysis. We then introduce the network that can be constructed using known lifespan and aging regulators, and conclude with a look forward to the future of systems biology in aging research. In summary, systems biology is not only a young field that may help us understand aging at a higher level, but also an important platform that can link different levels of knowledge on aging, moving us closer to a more comprehensive control of systematic decline during aging.
Keywords: Systems biology, Genomics, Proteomics, Longevity, Aging, Network analysis
Current Genomics
Title:Systems Biology in Aging: Linking the Old and the Young
Volume: 13 Issue: 7
Author(s): Lei Hou, Jialiang Huang, Christopher D. Green, Jerome Boyd-Kirkup, Wei Zhang, Xiaoming Yu, Wenxuan Gong, Bing Zhou and Jing-Dong J. Han
Affiliation:
Keywords: Systems biology, Genomics, Proteomics, Longevity, Aging, Network analysis
Abstract: Aging can be defined as a process of progressive decline in the physiological capacity of an organism, manifested by accumulated alteration and destabilization at the whole system level. Systems biology approaches offer a promising new perspective to examine the old problem of aging. We begin this review by introducing the concepts of systems biology, and then illustrate the application of systems biology approaches to aging research, from gene expression profiling to network analysis. We then introduce the network that can be constructed using known lifespan and aging regulators, and conclude with a look forward to the future of systems biology in aging research. In summary, systems biology is not only a young field that may help us understand aging at a higher level, but also an important platform that can link different levels of knowledge on aging, moving us closer to a more comprehensive control of systematic decline during aging.
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Cite this article as:
Hou Lei, Huang Jialiang, D. Green Christopher, Boyd-Kirkup Jerome, Zhang Wei, Yu Xiaoming, Gong Wenxuan, Zhou Bing and J. Han Jing-Dong, Systems Biology in Aging: Linking the Old and the Young, Current Genomics 2012; 13 (7) . https://dx.doi.org/10.2174/138920212803251418
DOI https://dx.doi.org/10.2174/138920212803251418 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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