Abstract
Impaired brain connectivity is a hallmark of schizophrenia brain dysfunction. However, the effect of drug treatment and challenges on the dysconnectivity of functional networks in schizophrenia is an understudied area. In this review, we provide an overview of functional magnetic resonance imaging studies examining dysconnectivity in schizophrenia and discuss the few studies which have also attempted to probe connectivity changes with antipsychotic drug treatment. We conclude with a discussion of possible avenues for further investigation.
Keywords: Antipsychotic drug treatment, brain connectivity, fMRI, schizophrenia
Current Neuropharmacology
Title:Brain Connectivity Studies in Schizophrenia: Unravelling the Effects of Antipsychotics
Volume: 10 Issue: 3
Author(s): Ayna B. Nejad, Bjorn H. Ebdrup, Birte Y. Glenthoj and Hartwig R. Siebner
Affiliation:
Keywords: Antipsychotic drug treatment, brain connectivity, fMRI, schizophrenia
Abstract: Impaired brain connectivity is a hallmark of schizophrenia brain dysfunction. However, the effect of drug treatment and challenges on the dysconnectivity of functional networks in schizophrenia is an understudied area. In this review, we provide an overview of functional magnetic resonance imaging studies examining dysconnectivity in schizophrenia and discuss the few studies which have also attempted to probe connectivity changes with antipsychotic drug treatment. We conclude with a discussion of possible avenues for further investigation.
Export Options
About this article
Cite this article as:
B. Nejad Ayna, H. Ebdrup Bjorn, Y. Glenthoj Birte and R. Siebner Hartwig, Brain Connectivity Studies in Schizophrenia: Unravelling the Effects of Antipsychotics, Current Neuropharmacology 2012; 10 (3) . https://dx.doi.org/10.2174/157015912803217305
DOI https://dx.doi.org/10.2174/157015912803217305 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Tubulin-Independent Tau in Alzheimer’s Disease and Cancer: Implications for Disease Pathogenesis and Treatment
Current Alzheimer Research Aqueous Extract of <i>Cola nitida</i> and <i>Garcinia kola</i> Synergistically Enhances Hippocampal-hypothalamic Glutamate and Na+ /K+ -ATPase Activity in Male Wistar Rats
Current Drug Discovery Technologies Behavioral and Neurochemical Studies in Distinct Animal Models of Ethanols Motivational Effects
Current Drug Abuse Reviews Microglia NLRP3 Inflammasomes Activation Involving Diabetic Neuroinflammation in Diabetic Mice and BV2 Cells
Current Pharmaceutical Design Lassa Virus Genome
Current Genomics Microglial Activation as a Compelling Target for Treating Acute Traumatic Brain Injury
Current Medicinal Chemistry MRI of Central Nervous System (CNS) Vasculitis
Current Medical Imaging The Perfect Storm: The High Prevalence Low Severity Outcomes of the Preterm Survivors
Current Pediatric Reviews mGluRI Targets Microglial Activation and Selectively Prevents Neuronal Cell Engulfment Through Akt and Caspase Dependent Pathways
Current Neurovascular Research Neuroimaging Correlates of 22q11.2 Deletion Syndrome: Implications for Schizophrenia Research
Current Topics in Medicinal Chemistry Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents
Current Neuropharmacology New Therapeutic Frontiers for Metabotropic Glutamate Receptors
Current Topics in Medicinal Chemistry Potential of Bone Marrow Stromal Cells in Applications for Neuro-Degenerative, Neuro-Traumatic and Muscle Degenerative Diseases
Current Neuropharmacology Neuroprotective Properties of Standardized Extracts of Hypericum perforatum on Rotenone Model of Parkinson’s Disease
CNS & Neurological Disorders - Drug Targets Episodic Memory Impairment in Frontotemporal Dementia; A <sup>99m</sup>Tc- HMPAO SPECT Study
Current Alzheimer Research PPAR-γ: Therapeutic Prospects in Parkinson's Disease
Current Drug Targets Nonsynaptic Receptors for GABA and Glutamate
Current Topics in Medicinal Chemistry Nongenomic Actions of Thyroid Hormones: From Basic Research to Clinical Applications. An Update
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Exploring the Relationship of Functional Network Connectivity to Latent Trajectories of Alcohol Use and Risky Sex
Current HIV Research Mechanisms of Melatonin in Alleviating Alzheimer’s Disease
Current Neuropharmacology