Abstract
The analysis of drugs in various biological fluids is an important criterion for the determination of the physiological performance of a drug. NSAIDs are non-selective inhibitors of prostaglandin biosynthesis and indicated for the acute or long-term treatment of the signs and symptoms of rheumatoid arthritis and osteoarthritis. This paper reviews the recent developments in bioanalysis of these drugs. In particular, sample preparation end, handling procedures, chromatographic conditions and detection methods are discussed. A summary of published HPLC assays for individual antiinflammatory drugs is included.
Keywords: NSAIDs, enantiomers, biological fluids, HPLC, prostaglandin biosynthesis, antipyretic drugs, antinflammatory drugs, Etodolac, Fenoprofen, carboxyibuprofen metabolites, non-selective inhibitors, rheumatoid arthritis, osteoarthritis, HPLC assays, pharmacokinetics, chiral drug molecules
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:Analysis of Anti-Inflammatory Enantiomers by HPLC in Human Plasma and Urine: A Review
Volume: 11 Issue: 1
Author(s): Giuseppe Carlucci, Maura Carlucci and Marcello Locatelli
Affiliation:
Keywords: NSAIDs, enantiomers, biological fluids, HPLC, prostaglandin biosynthesis, antipyretic drugs, antinflammatory drugs, Etodolac, Fenoprofen, carboxyibuprofen metabolites, non-selective inhibitors, rheumatoid arthritis, osteoarthritis, HPLC assays, pharmacokinetics, chiral drug molecules
Abstract: The analysis of drugs in various biological fluids is an important criterion for the determination of the physiological performance of a drug. NSAIDs are non-selective inhibitors of prostaglandin biosynthesis and indicated for the acute or long-term treatment of the signs and symptoms of rheumatoid arthritis and osteoarthritis. This paper reviews the recent developments in bioanalysis of these drugs. In particular, sample preparation end, handling procedures, chromatographic conditions and detection methods are discussed. A summary of published HPLC assays for individual antiinflammatory drugs is included.
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Carlucci Giuseppe, Carlucci Maura and Locatelli Marcello, Analysis of Anti-Inflammatory Enantiomers by HPLC in Human Plasma and Urine: A Review, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2012; 11 (1) . https://dx.doi.org/10.2174/187152312803476228
DOI https://dx.doi.org/10.2174/187152312803476228 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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