Abstract
The analysis of drugs in various biological fluids is an important criterion for the determination of the physiological performance of a drug. NSAIDs are non-selective inhibitors of prostaglandin biosynthesis and indicated for the acute or long-term treatment of the signs and symptoms of rheumatoid arthritis and osteoarthritis. This paper reviews the recent developments in bioanalysis of these drugs. In particular, sample preparation end, handling procedures, chromatographic conditions and detection methods are discussed. A summary of published HPLC assays for individual antiinflammatory drugs is included.
Keywords: NSAIDs, enantiomers, biological fluids, HPLC, prostaglandin biosynthesis, antipyretic drugs, antinflammatory drugs, Etodolac, Fenoprofen, carboxyibuprofen metabolites, non-selective inhibitors, rheumatoid arthritis, osteoarthritis, HPLC assays, pharmacokinetics, chiral drug molecules
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:Analysis of Anti-Inflammatory Enantiomers by HPLC in Human Plasma and Urine: A Review
Volume: 11 Issue: 1
Author(s): Giuseppe Carlucci, Maura Carlucci and Marcello Locatelli
Affiliation:
Keywords: NSAIDs, enantiomers, biological fluids, HPLC, prostaglandin biosynthesis, antipyretic drugs, antinflammatory drugs, Etodolac, Fenoprofen, carboxyibuprofen metabolites, non-selective inhibitors, rheumatoid arthritis, osteoarthritis, HPLC assays, pharmacokinetics, chiral drug molecules
Abstract: The analysis of drugs in various biological fluids is an important criterion for the determination of the physiological performance of a drug. NSAIDs are non-selective inhibitors of prostaglandin biosynthesis and indicated for the acute or long-term treatment of the signs and symptoms of rheumatoid arthritis and osteoarthritis. This paper reviews the recent developments in bioanalysis of these drugs. In particular, sample preparation end, handling procedures, chromatographic conditions and detection methods are discussed. A summary of published HPLC assays for individual antiinflammatory drugs is included.
Export Options
About this article
Cite this article as:
Carlucci Giuseppe, Carlucci Maura and Locatelli Marcello, Analysis of Anti-Inflammatory Enantiomers by HPLC in Human Plasma and Urine: A Review, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2012; 11 (1) . https://dx.doi.org/10.2174/187152312803476228
DOI https://dx.doi.org/10.2174/187152312803476228 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Exercise and Cognitive-Behavioural Treatment in Fibromyalgia Syndrome
Current Pharmaceutical Design MicroRNA Therapies for Osteoarthritis and its Symptoms
Current Tissue Engineering (Discontinued) Gold(III) Complexes in the Oncological Preclinical Arena: From Aminoderivatives to Peptidomimetics
Current Topics in Medicinal Chemistry New Analytical Tools for Studying Autoimmune Diseases
Current Pharmaceutical Design Compositions for Treatment of Cancer and Inflammation
Recent Patents on Anti-Cancer Drug Discovery Clinical Applications of the Urokinase Receptor (uPAR) for Cancer Patients
Current Pharmaceutical Design Intracellular Logistics of BST-2/Tetherin
Current HIV Research The Immunoproteasome: An Emerging Therapeutic Target
Current Topics in Medicinal Chemistry S100A9 Exacerbates the Aβ1-42-mediated Innate Immunity in Human THP-1 Monocytes
CNS & Neurological Disorders - Drug Targets Chemokines and Receptors as Targets in Anti-Inflammatory Therapy
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Tumor Necrosis Factor-a Blockade in Rheumatoid Arthritis: Responders Vs Non Responders
Medicinal Chemistry Reviews - Online (Discontinued) Pyrazoles as Promising Scaffold for the Synthesis of Anti-Inflammatory and/or Antimicrobial Agent: A Review
Mini-Reviews in Medicinal Chemistry Patent Selections
Recent Patents on Inflammation & Allergy Drug Discovery Adult Stem Cells for Cartilage Tissue Engineering and Regeneration
Current Rheumatology Reviews Bacterial Urease and its Role in Long-Lasting Human Diseases
Current Protein & Peptide Science Role of Sulfonamide Group in Matrix Metalloproteinase Inhibitors
Current Medicinal Chemistry Body Mass Index Impact on Disease Activity, Clinical and Sonographic Remission Rates in Patients with Rheumatoid Arthritis
Current Rheumatology Reviews Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance
Current Neuropharmacology Microwave Assisted Synthesis of Five Membered Azaheterocyclic Systems
Current Organic Chemistry Bone Changes in Patients with Inflammatory Arthritis Treated with Biological Therapies: A Clinical Perspective
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued)