Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of often chemically unrelated compounds with some common therapeutic actions and side effects. They have potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. It is generally thought that one of their main mechanisms of action is the inhibition of cyclo-oxygenase (COX), the enzyme responsible for biosynthesing the prostaglandins and thromboxane. NSAIDs are also associated with an increased risk of adverse gastrointestinal, renal and cardiovascular effects. This review describes the clinical pharmacology of NSAIDs, their classification, molecular mechanisms of action and adverse effects, including their possible contribution to neuro-inflammation and carcinogenesis, as well as some recent developments aimed at designing effective anti-inflammatory agents with improved safety and tolerability profiles.
Keywords: NSAIDs, cyclo-oxygenases, prostanoids, adverse effects, cancer, neuro-inflammation, safe NSAIDs, Non-Steroidal Anti-Inflammatory Drugs, selective COX-2 inhibitors , COXIBs, COX-1 , COX-2 , enzyme catalysis , cytoprotection, Hydrogen sulfide-releasing non-steroidal anti-inflammatory, Nitric oxide-releasing non-steroidal anti-inflammatory
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:Clinical Pharmacology of Non-Steroidal Anti-Inflammatory Drugs: A Review
Volume: 11 Issue: 1
Author(s): S. Bacchi, P. Palumbo, A. Sponta and M.F. Coppolino
Affiliation:
Keywords: NSAIDs, cyclo-oxygenases, prostanoids, adverse effects, cancer, neuro-inflammation, safe NSAIDs, Non-Steroidal Anti-Inflammatory Drugs, selective COX-2 inhibitors , COXIBs, COX-1 , COX-2 , enzyme catalysis , cytoprotection, Hydrogen sulfide-releasing non-steroidal anti-inflammatory, Nitric oxide-releasing non-steroidal anti-inflammatory
Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of often chemically unrelated compounds with some common therapeutic actions and side effects. They have potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. It is generally thought that one of their main mechanisms of action is the inhibition of cyclo-oxygenase (COX), the enzyme responsible for biosynthesing the prostaglandins and thromboxane. NSAIDs are also associated with an increased risk of adverse gastrointestinal, renal and cardiovascular effects. This review describes the clinical pharmacology of NSAIDs, their classification, molecular mechanisms of action and adverse effects, including their possible contribution to neuro-inflammation and carcinogenesis, as well as some recent developments aimed at designing effective anti-inflammatory agents with improved safety and tolerability profiles.
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Bacchi S., Palumbo P., Sponta A. and Coppolino M.F., Clinical Pharmacology of Non-Steroidal Anti-Inflammatory Drugs: A Review, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2012; 11 (1) . https://dx.doi.org/10.2174/187152312803476255
DOI https://dx.doi.org/10.2174/187152312803476255 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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