Abstract
Resuscitation promoting factors (Rpf) are a family of proteins secreted by actively growing actinobacteria, including Mycobacterium tuberculosis. Experimental evidence suggests that Rpfs play a distinct role in bacterial resuscitation and re-growth as well as reactivation of chronic tuberculosis in mice. The striking similarity of the Rpfs structure to cell wall hydrolysing enzymes has provided a basis for the development of novel low molecular weight inhibitors of Rpfs activity. In particular, recently characterised nitrophenylthiocyanate compounds could be considered as a promising scaffold for generation of therapeutic agents targeting reactivation of latent tuberculosis. This review describes recent progress in understanding of molecular mechanisms of Rpf biological activity.
Keywords: Inhibitors, latency, nitrophenylthiocyanates, resuscitation, Rpf, tuberculosis, Mycobacterium tuberculosis, cell wall hydrolysing enzymes, therapeutic agents, molecular mechanisms
Protein & Peptide Letters
Title:Resuscitation-promoting Factors (Rpf): In Search of Inhibitors
Volume: 19 Issue: 10
Author(s): Arseny S. Kaprelyants, Galina V. Mukamolova, Alessia Ruggiero, Vadim A. Makarov, Galina R. Demina, Margarita O. Shleeva, Vasilii D. Potapov and Pavel A. Shramko
Affiliation:
Keywords: Inhibitors, latency, nitrophenylthiocyanates, resuscitation, Rpf, tuberculosis, Mycobacterium tuberculosis, cell wall hydrolysing enzymes, therapeutic agents, molecular mechanisms
Abstract: Resuscitation promoting factors (Rpf) are a family of proteins secreted by actively growing actinobacteria, including Mycobacterium tuberculosis. Experimental evidence suggests that Rpfs play a distinct role in bacterial resuscitation and re-growth as well as reactivation of chronic tuberculosis in mice. The striking similarity of the Rpfs structure to cell wall hydrolysing enzymes has provided a basis for the development of novel low molecular weight inhibitors of Rpfs activity. In particular, recently characterised nitrophenylthiocyanate compounds could be considered as a promising scaffold for generation of therapeutic agents targeting reactivation of latent tuberculosis. This review describes recent progress in understanding of molecular mechanisms of Rpf biological activity.
Export Options
About this article
Cite this article as:
S. Kaprelyants Arseny, V. Mukamolova Galina, Ruggiero Alessia, A. Makarov Vadim, R. Demina Galina, O. Shleeva Margarita, D. Potapov Vasilii and A. Shramko Pavel, Resuscitation-promoting Factors (Rpf): In Search of Inhibitors, Protein & Peptide Letters 2012; 19 (10) . https://dx.doi.org/10.2174/092986612802762723
DOI https://dx.doi.org/10.2174/092986612802762723 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cytokines in Systemic Lupus Erythematosus
Current Molecular Medicine Interethnic and Intraethnic Variability of NAT2 Single Nucleotide Polymorphisms
Current Drug Metabolism The Potent Antiplasmodial Calmodulin-Antagonist Trifluoperazine Inhibits Plasmodium falciparum Calcium-Dependent Protein Kinase 4
Protein & Peptide Letters Pharmacological Innovations for Posttraumatic Stress Disorder and Medication- Enhanced Psychotherapy
Current Pharmaceutical Design Commentary: Drugs From Bugs
Current Protein & Peptide Science Vitamins in the Prevention or Delay of Cognitive Disability of Aging
Current Aging Science The 4-Quinolone-3-Carboxylic Acid Motif as a Multivalent Scaffold in Medicinal Chemistry
Current Medicinal Chemistry Targeting Bacterial RNA Polymerase σ70 for Development of Broadspectrum Antisense Antibacterials
Recent Patents on Anti-Infective Drug Discovery β-Carboline Alkaloids: Biochemical and Pharmacological Functions
Current Medicinal Chemistry Patent Selections
Recent Patents on Drug Delivery & Formulation Biomarkers and Pneumonia: Should We All be Using Them?
Current Respiratory Medicine Reviews Design and Synthesis of (<i>E</i>)-4-(2-Phenyl-2<i>H</i>-chromen-3-yl)but-3-en-2-ones and Evaluation of their <i>In Vitro</i> Antimicrobial Activity
Letters in Organic Chemistry From Nucleic Acids to Drug Discovery: Nucleobases as Emerging Templates for Drug Candidates
Current Medicinal Chemistry Biocombinatorial Selection of Carbohydrate Binding Agents of Therapeutic Significance
Current Drug Discovery Technologies An Acetylated Triterpene Glycoside and Lignans from <i>Phyllanthus myrtifolius</i> and their Antibacterial Activities
The Natural Products Journal A Rational Approach to Identify Inhibitors of Mycobacterium tuberculosis Enoyl Acyl Carrier Protein Reductase
Current Pharmaceutical Design The Antibiotics in the Chemical Space
Current Medicinal Chemistry Heart Score Estimation by Specialized Nurses in a Greek Urban Population
Current Vascular Pharmacology Antimycobacterial Activities of Oxazolidinones: A Review
Infectious Disorders - Drug Targets Patent Selections
Recent Patents on Anti-Infective Drug Discovery