Abstract
The most commonly encountered carcinoma of the sinonasal tract is the keratinizing/ non-keratinizing squamous cell carcinoma. However, this complex anatomic location may represent the site of other epithelial malignant neoplasms of varying histogenesis. These tumors are clinically aggressive and often fatal; historically, treatment outcomes have been poor. Differentiating these tumor types may have clinical impact as advances in therapeutic intervention could increase survival, quality of life and occasionally result in a cure. This review focuses on recent advances in the molecular and phenotypic characterization of sinonasal carcinomas and their impact on diagnosis and treatment.
Keywords: Sinonasal carcinoma, Phenotype, Genome analysis, Targeted therapy
Current Cancer Therapy Reviews
Title:Sinonasal Carcinoma: Updated Phenotypic and Molecular Characterization
Volume: 8 Issue: 3
Author(s): Diana Bell and Ehab Y. Hanna
Affiliation:
Keywords: Sinonasal carcinoma, Phenotype, Genome analysis, Targeted therapy
Abstract: The most commonly encountered carcinoma of the sinonasal tract is the keratinizing/ non-keratinizing squamous cell carcinoma. However, this complex anatomic location may represent the site of other epithelial malignant neoplasms of varying histogenesis. These tumors are clinically aggressive and often fatal; historically, treatment outcomes have been poor. Differentiating these tumor types may have clinical impact as advances in therapeutic intervention could increase survival, quality of life and occasionally result in a cure. This review focuses on recent advances in the molecular and phenotypic characterization of sinonasal carcinomas and their impact on diagnosis and treatment.
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Cite this article as:
Bell Diana and Y. Hanna Ehab, Sinonasal Carcinoma: Updated Phenotypic and Molecular Characterization, Current Cancer Therapy Reviews 2012; 8 (3) . https://dx.doi.org/10.2174/157339412802653137
DOI https://dx.doi.org/10.2174/157339412802653137 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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