Resolving Biofilm Infections: Current Therapy and Drug Discovery Strategies

Title:Resolving Biofilm Infections: Current Therapy and Drug Discovery Strategies

Volume: 13 Issue: 11

Author(s): Max V. Ranall, Mark S. Butler, Mark A. Blaskovich and Matthew A. Cooper

Affiliation:

Keywords: Antibiotic, antibiotic resistance, bacteria, biofilm, drug discovery, infection, screening, pathogenic bacteria, assays.

Abstract: Biofilms formed by pathogenic bacteria present a serious threat to human health as the efficacy of standard antibiotic therapeutic regimens is compromised by reduced microbial susceptibility within the biofilm environment. The discovery of improved therapies for biofilm elimination requires an understanding of biofilm formation and dispersal, and the development of assays to specifically analyze these dynamic processes. This review will discuss biofilm screening strategies suitable for drug discovery efforts, especially chemical and biological approaches that specifically target biofilm destruction.

Cite this article as:

V. Ranall Max, S. Butler Mark, A. Blaskovich Mark and A. Cooper Matthew, Resolving Biofilm Infections: Current Therapy and Drug Discovery Strategies, Current Drug Targets 2012; 13 (11) . https://dx.doi.org/10.2174/138945012803530251