Abstract
Polyphenol-protein interaction (PPI) is reversible in that polyphenol-protein complex can be dissociated and release the free polyphenols. The aim of this study is to evaluate the contribution of polyphenol-protein interaction on improving the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging capacity of polyphenols. The DPPH radical scavenging potential of polyphenols was determined from 1 to 7 days under aerobic condition. The DPPH radical scavenging capacity of polyphenols depended on the structures of dietary polyphenols and gallic acids. The DPPH radical scavenging percentages of Group H polyphenols were weakened when kept in room temperature from 1 to 7 days. BSA rapid weakened the DPPH radical scavenging activity of polyphenols on the first day. However, the DPPH scavenging capacities of polyphenols in the presence of BSA overwhelmingly improved with increasing time. These results illustrated that BSA not only prolongs the effective time, but also improved the DPPH radical scavenging potential of polyphenols. The increasing DPPH scavenging percentages of polyphenols slightly decreased with increased affinities of BSA-polyphenol complexes.
Keywords: Polypenol-protein interaction, DPPH scavenging capacity, Protein binding, Polyphenols, Gallic acids, antioxidant, ethylbenzothiazoline, apigenin, puerarin, epicatechin
Anti-Cancer Agents in Medicinal Chemistry
Title:Bovine Serum Albumin Significantly Improves the DPPH Free Radical Scavenging Potential of Dietary Polyphenols and Gallic Acids
Volume: 12 Issue: 8
Author(s): Hui Cao, Xiaoqing Chen and Koichiro Yamamoto
Affiliation:
Keywords: Polypenol-protein interaction, DPPH scavenging capacity, Protein binding, Polyphenols, Gallic acids, antioxidant, ethylbenzothiazoline, apigenin, puerarin, epicatechin
Abstract: Polyphenol-protein interaction (PPI) is reversible in that polyphenol-protein complex can be dissociated and release the free polyphenols. The aim of this study is to evaluate the contribution of polyphenol-protein interaction on improving the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging capacity of polyphenols. The DPPH radical scavenging potential of polyphenols was determined from 1 to 7 days under aerobic condition. The DPPH radical scavenging capacity of polyphenols depended on the structures of dietary polyphenols and gallic acids. The DPPH radical scavenging percentages of Group H polyphenols were weakened when kept in room temperature from 1 to 7 days. BSA rapid weakened the DPPH radical scavenging activity of polyphenols on the first day. However, the DPPH scavenging capacities of polyphenols in the presence of BSA overwhelmingly improved with increasing time. These results illustrated that BSA not only prolongs the effective time, but also improved the DPPH radical scavenging potential of polyphenols. The increasing DPPH scavenging percentages of polyphenols slightly decreased with increased affinities of BSA-polyphenol complexes.
Export Options
About this article
Cite this article as:
Cao Hui, Chen Xiaoqing and Yamamoto Koichiro, Bovine Serum Albumin Significantly Improves the DPPH Free Radical Scavenging Potential of Dietary Polyphenols and Gallic Acids, Anti-Cancer Agents in Medicinal Chemistry 2012; 12 (8) . https://dx.doi.org/10.2174/187152012802650101
DOI https://dx.doi.org/10.2174/187152012802650101 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Multicomponent One-Pot Reactions: Synthesis of Some New 6-Oxopyrano [2,3-c]Isochromenes by Condensation of Homophthalic Anhydride, Dialkyl acetylenedicarboxylate, and Isocyanides
Combinatorial Chemistry & High Throughput Screening Extracellular Proteases as Targets for Drug Development
Current Protein & Peptide Science A Review of Denoising Medical Images Using Machine Learning Approaches
Current Medical Imaging Synthesis and Antiproliferative Effects of 5,6-Disubstituted Pyridazin-3(2H)-ones Designed as Conformationally Constrained Combretastatin A-4 Analogues
Anti-Cancer Agents in Medicinal Chemistry Natural Compounds Promoting Weight Loss: Mechanistic Insights from the Point of View of the Medicinal Chemist
The Natural Products Journal Recent Developments in Breast Tomosynthesis Imaging
Recent Patents on Medical Imaging Discrepant mRNA and Protein Expression in Immune Cells
Current Genomics Application of Multivariate Linear and Nonlinear Calibration and Classification Methods in Drug Design
Combinatorial Chemistry & High Throughput Screening Discover Patent Landscape of Two-photon Polymerization Technology for the Production of 3D Nano-structure Using Claim-based Approach
Recent Patents on Nanotechnology Novel Biomarkers Assessing the Calcium Deposition in Coronary Artery Disease
Current Medicinal Chemistry Performance Identification Using Morphological Approach on Digital Mammographic Images
Current Signal Transduction Therapy Ionic Liquids: A New Strategy in Pharmaceutical Synthesis
Mini-Reviews in Organic Chemistry Linear Poly(ethylenimine) Cross-Linked by Methyl-β-Cyclodextrin for Gene Delivery
Current Gene Therapy Chemical Advances in Therapeutic Application of Exosomes and Liposomes
Current Medicinal Chemistry Development of Multifunctional Nanoparticles for Targeted Drug Delivery and Noninvasive Imaging of Therapeutic Effect
Current Drug Discovery Technologies Therapeutic Proteins: A to Z
Protein & Peptide Letters Cytotoxic T Cell Reponses Against Immunoglobulin in Malignant and Normal B Cells: Implications for Tumor Immunity and Autoimmunity
Current Pharmaceutical Design Melittin: A Natural Peptide with Expanded Therapeutic Applications
The Natural Products Journal Nutraceuticals: Beyond the Diet Before the Drugs
Current Bioactive Compounds Aldo-Keto Reductase Family 1 Member B1 Inhibitors: Old Drugs with New Perspectives
Recent Patents on Anti-Cancer Drug Discovery