Lipoamino Acids as Major Components of Absorption Promoters in Drug Delivery

Zyta      M. Ziora; Mark      A. Blaskovich; Istvan      Toth; Matthew      A. Cooper

Abstract

Many biologically active compounds are unsuitable for development as drugs due to their poor bioavailability. For hydrophilic compounds, modifications to increase lipophilicity can increase passive diffusion or increase uptake into the lymphatic system. Alternatively, improved bioavailability of hydrophilic drug candidates may be achieved by formulation with absorption promoters such as surfactants, penetration enhancers, or ion pairing agents. This approach to enhancing bioavailability also has the potential to widen the range of compound categories that can be used as chemical probes to study biological systems in cells and in vivo where membrane permeability would otherwise be a significant limitation. Lipidic amino acids, which combine the structural properties of lipids with those of α-amino acids, represent a relatively unexplored class of agents that can improve drug adsorption. This review discusses the potential of absorption promoters possessing lipoamino acids for improving drug bioavailability.

Keywords: Absorption promoter, dendrimers, drug bioavailability, drug delivery, ion pairing agents, lipoamino acids, penetration enhancers, hydrophilic compounds, lymphatic system, hydrophilic drug, chemical probes, biological systems in cells, Lipidic amino acids