Abstract
Bladder cancer is the second most common malignancy of urinary tract. Normal bladder urothelium is a transitional epithelium which consist of 3-7 layers and three different types of cells. The question is what kind of cells is responsible for bladder cancer development, probably stem cells? Stem cells can be sensitive to changes in their environment including toxic substances related to smoking. These changes within stem cells may potentially induce carcinogenesis by limiting their differentiating potential but expanding their proliferative potential. This process is directly connected with stem cell senescence in which DNA alterations play an important role. Cancer stem cells have become the target in treating various cancers. Tumor initiating cells within bladder cancer have been isolated. It has to be tested what connections are between cancer stem cells and tumor initiating cells. Characteristic markers and proteins may help to identify bladder cancer stem cells and thus early stages of bladder cancer. Moreover, bladder cancer stem cells undergo signaling pathways which play critical role both in normal and cancer stem cells.
Keywords: Cancer stem cell, tumor biology, urinary bladder, carcinogenesis, phenotypic, metastatic, Neoplastic cells, post-mitotic, glycoproteins, lymphocyte
Current Signal Transduction Therapy
Title:Bladder Cancer and Stem Cells
Volume: 7 Issue: 3
Author(s): Tomasz Drewa, Sandra Krzyzanowska, Andrzej Marszalek and Anna Bajek
Affiliation:
Keywords: Cancer stem cell, tumor biology, urinary bladder, carcinogenesis, phenotypic, metastatic, Neoplastic cells, post-mitotic, glycoproteins, lymphocyte
Abstract: Bladder cancer is the second most common malignancy of urinary tract. Normal bladder urothelium is a transitional epithelium which consist of 3-7 layers and three different types of cells. The question is what kind of cells is responsible for bladder cancer development, probably stem cells? Stem cells can be sensitive to changes in their environment including toxic substances related to smoking. These changes within stem cells may potentially induce carcinogenesis by limiting their differentiating potential but expanding their proliferative potential. This process is directly connected with stem cell senescence in which DNA alterations play an important role. Cancer stem cells have become the target in treating various cancers. Tumor initiating cells within bladder cancer have been isolated. It has to be tested what connections are between cancer stem cells and tumor initiating cells. Characteristic markers and proteins may help to identify bladder cancer stem cells and thus early stages of bladder cancer. Moreover, bladder cancer stem cells undergo signaling pathways which play critical role both in normal and cancer stem cells.
Export Options
About this article
Cite this article as:
Drewa Tomasz, Krzyzanowska Sandra, Marszalek Andrzej and Bajek Anna, Bladder Cancer and Stem Cells, Current Signal Transduction Therapy 2012; 7 (3) . https://dx.doi.org/10.2174/157436212802481556
DOI https://dx.doi.org/10.2174/157436212802481556 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Meet Our Editorial Board Member
Current Protein & Peptide Science Heat Shock Proteins (HSPs) Based Anti-Cancer Vaccines
Current Molecular Medicine CETUXIMAB: From Bench to Bedside
Current Cancer Drug Targets Identification and Characterization of New Proteins in Podocyte Dysfunction of Membranous Nephropathy by Proteomic Analysis of Renal Biopsy
Current Pharmacogenomics and Personalized Medicine Synthesis and Anti-cancer Activities of Apigenin Derivatives
Medicinal Chemistry Introduction: P2 Receptors
Current Topics in Medicinal Chemistry Risk Factors for Serious Adverse Effects of Thiopurines in Patients with Crohn’s Disease
Current Drug Safety Medicinal Chemistry of Selective Neurokinin-1 Antagonists
Current Topics in Medicinal Chemistry Analysis of Key GO Terms and KEGG Pathways Associated with Carcinogenic Chemicals
Combinatorial Chemistry & High Throughput Screening Looking at Drug Resistance Mechanisms for Microtubule Interacting Drugs: Does TUBB3 Work?
Current Cancer Drug Targets Insulin-like Effects of Mt. Fuji Subsoil Water which Conta ins Vanadium on Cultured Cells: Insight from Japan
Current Traditional Medicine Four-Component Synthesis of 1,2-Dihydropyridine Derivatives and their Evaluation as Anticancer Agents
Medicinal Chemistry Nucleic Acid-based Technologies in Therapy of Malignant Gliomas
Current Pharmaceutical Biotechnology Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells
Mini-Reviews in Medicinal Chemistry Hepatic Steatosis and Peroxisomal Fatty Acid Beta-oxidation
Current Drug Metabolism Modulation of intracellular pH in human ovarian cancer.
Current Molecular Medicine Cranberry for Urinary Tract Infection: From Bench to Bedside
Current Topics in Medicinal Chemistry Cancer Stem Cell Model in Oral Squamous Cell Carcinoma
Current Stem Cell Research & Therapy Voltage-Dependent Potassium Channels Kv1.3 and Kv1.5 in Human Cancer
Current Cancer Drug Targets 2-Deoxy-D-Ribose, a Downstream Mediator of Thymidine Phosphorylase, Regulates Tumor Angiogenesis and Progression
Anti-Cancer Agents in Medicinal Chemistry