Abstract
Resveratrol (3,5,4'-trans-trihydroxystilbene) is a naturally occurring phytoalexin that is found in medicinal plants, grape skin, peanuts and red wine. Resveratrol exhibits a remarkable range of biological activities, including anticancer activity, antitubulin activity, anti-cardiovascular disease activity, etc. Several other natural products are structurally similar to resveratrol and also present in food. In addition, a series of resveratrol derivatives have been synthesized by the addition of defined functional groups to increase the potency or enhance the activity of specific properties of resveratrol. These resveratrol derivatives might provide promising functions as cardiovascular disease chemopreventive agents. In this review, we will attempt to summarize the main developments of resveratrol derivatives in cardiovascular disease and the main developments have occurred in derivatives of resveratrol’s structure-activity relationship and cardiovascular disease over the last couple of decades.
Keywords: Cardiovascular disease, reactive oxygen species, apoptosis, SIRT1, AMPK, Akt, derivatives of resveratrol, structure-activity relationship, structure-activity, relationship, phytoalexin.
Current Medicinal Chemistry
Title:Derivatives of Resveratrol: Potential Agents in Prevention and Treatment of Cardiovascular Disease
Volume: 19 Issue: 24
Author(s): Ban-Feng Ruan, Xiao-Qin Lu, Jie Song and Hai-Liang Zhu
Affiliation:
Keywords: Cardiovascular disease, reactive oxygen species, apoptosis, SIRT1, AMPK, Akt, derivatives of resveratrol, structure-activity relationship, structure-activity, relationship, phytoalexin.
Abstract: Resveratrol (3,5,4'-trans-trihydroxystilbene) is a naturally occurring phytoalexin that is found in medicinal plants, grape skin, peanuts and red wine. Resveratrol exhibits a remarkable range of biological activities, including anticancer activity, antitubulin activity, anti-cardiovascular disease activity, etc. Several other natural products are structurally similar to resveratrol and also present in food. In addition, a series of resveratrol derivatives have been synthesized by the addition of defined functional groups to increase the potency or enhance the activity of specific properties of resveratrol. These resveratrol derivatives might provide promising functions as cardiovascular disease chemopreventive agents. In this review, we will attempt to summarize the main developments of resveratrol derivatives in cardiovascular disease and the main developments have occurred in derivatives of resveratrol’s structure-activity relationship and cardiovascular disease over the last couple of decades.
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Cite this article as:
Ruan Ban-Feng, Lu Xiao-Qin, Song Jie and Zhu Hai-Liang, Derivatives of Resveratrol: Potential Agents in Prevention and Treatment of Cardiovascular Disease, Current Medicinal Chemistry 2012; 19 (24) . https://dx.doi.org/10.2174/092986712802430054
DOI https://dx.doi.org/10.2174/092986712802430054 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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