Modified Alginate Beads for Mucoadhesive Drug Delivery System: An Updated Review of Patents

Suryakanta      Swain; Aurobinda      Behera; Sarwar      Beg; Chinam      N. Patra; Subash      C. Dinda; Jammula      Sruti; Muddana      E. B. Rao

Abstract

Pharmaceutical research and inventions are increasingly developed for the design of an ideal dosage regimen in drug therapy of many diseases, which attains therapeutic concentration of drug in plasma and maintains it constant for the entire duration of treatment and also minimizes the side effects. Recent trends in pharmaceutical technology indicated that mucoadhesive micro particle and modified alginate beads as drug delivery system especially suitable for achieving delivery of drug in a predetermined rate locally or systemically for a prolonged period of time. The release of drug from microparticle depends on a variety of factors including carrier used to form the micro particle and amount of drug contained in them. The main aim of the present review is to explain the various theories, mechanisms, advanced mucoadhesive polymers, various delivery approaches, methodologies for developing a mucoadhesive micro-particle and modified alginate beads formulation, in vitro, ex vivo and in vivo characterization. Apart from this, an innovative test method that is biacore is highlighted in this review to measure the mucoadhesive strength. This review is also briefly explained about the updated patenting system for the development of micro-particle and modified alginate beads as drug delivery system.

Keywords: Biacore, delivery approaches, modified alginate beads, pharmacokinetic advantages, recent patents, MUCOADHESIVE MICROPARTICLE, Wetting Theory, Fracture Theory, Iontropic Gelation, Spray Drying.