Abstract
Capsule endoscopy (CE) represents a significant advance in the investigation of small bowel diseases. Twothirds of Crohn’s disease (CD) patients have small bowel involvement at diagnosis. Study of small intestine mucosa by CE may have a strong impact on CD management in a near future. CE may be superior to small bowel cross-sectional imaging for detection of mucosal lesions consistent with CD and a normal CE has a high negative predictive value for active small bowel CD. A GI imaging study should generally precede CE to rule out complications such as fistulas and strictures. In established CD, CE may be useful in patients with unexplained symptoms when other investigations are inconclusive, if this will alter management. The low specificity of CE is its main drawback. Furthermore, there are no validated CD diagnosis criteria for CE and no severity indexes have been independently validated. The role of CE in evaluating mucosal healing and postoperative recurrence will require additional investigation.
Keywords: Capsule endoscopy, Crohn’s disease, small bowel diseases, cross-sectional imaging, mucosal lesions, GI imaging, mucosal healing, detection, gastrointestinal (GI), inflammatory bowel disease unclassified (IBDU).
Current Drug Targets
Title:Capsule Endoscopy in Crohn’s Disease
Volume: 13 Issue: 10
Author(s): Jean-Baptiste Chevaux, Gionata Fiorino, Muriel Frederic and Laurent Peyrin-Biroulet
Affiliation:
Keywords: Capsule endoscopy, Crohn’s disease, small bowel diseases, cross-sectional imaging, mucosal lesions, GI imaging, mucosal healing, detection, gastrointestinal (GI), inflammatory bowel disease unclassified (IBDU).
Abstract: Capsule endoscopy (CE) represents a significant advance in the investigation of small bowel diseases. Twothirds of Crohn’s disease (CD) patients have small bowel involvement at diagnosis. Study of small intestine mucosa by CE may have a strong impact on CD management in a near future. CE may be superior to small bowel cross-sectional imaging for detection of mucosal lesions consistent with CD and a normal CE has a high negative predictive value for active small bowel CD. A GI imaging study should generally precede CE to rule out complications such as fistulas and strictures. In established CD, CE may be useful in patients with unexplained symptoms when other investigations are inconclusive, if this will alter management. The low specificity of CE is its main drawback. Furthermore, there are no validated CD diagnosis criteria for CE and no severity indexes have been independently validated. The role of CE in evaluating mucosal healing and postoperative recurrence will require additional investigation.
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Cite this article as:
Chevaux Jean-Baptiste, Fiorino Gionata, Frederic Muriel and Peyrin-Biroulet Laurent, Capsule Endoscopy in Crohn’s Disease, Current Drug Targets 2012; 13 (10) . https://dx.doi.org/10.2174/138945012802429732
DOI https://dx.doi.org/10.2174/138945012802429732 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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