Abstract
Condensation of 2-acetyl-1-naphthol and 1-acetyl-2-naphthol with benzaldehydes under microwave irradiation gave chalcones or flavanones depending on the type of ketone. Also, 2-pyrazolines were synthesized by the condensation of chalcones with phenyl hydrazine under microwave irradiation in presence of dry acetic acid as a cyclizing agent. The results obtained indicated that, unlike classical heating, microwave irradiation resulted in higher yields, shorter reaction times and cleaner reactions. The structures of the synthesized compounds were elucidated using various spectroscopic methods. Theoretical studies explained the behaviour and reactivity observed for 1-acetyl-2-naphthol with benzaldehydes considering geometries, and electron densities of the formed flavanones.
Keywords: 1-Acetyl-2-naphthol, 2-Acetyl-1-naphthol, 2-Pyrazolines, chalcones, flavanones, microwave irradiation, anticancer, antinflammatory, antimalarial, anti-AIDS
Letters in Organic Chemistry
Title:Microwave–assisted Synthesis of Chalcones, Flavanones and 2- pyrazolines: Theoretical and Experimental Study
Volume: 9 Issue: 7
Author(s): Abdullah S. Al-Bogami
Affiliation:
Keywords: 1-Acetyl-2-naphthol, 2-Acetyl-1-naphthol, 2-Pyrazolines, chalcones, flavanones, microwave irradiation, anticancer, antinflammatory, antimalarial, anti-AIDS
Abstract: Condensation of 2-acetyl-1-naphthol and 1-acetyl-2-naphthol with benzaldehydes under microwave irradiation gave chalcones or flavanones depending on the type of ketone. Also, 2-pyrazolines were synthesized by the condensation of chalcones with phenyl hydrazine under microwave irradiation in presence of dry acetic acid as a cyclizing agent. The results obtained indicated that, unlike classical heating, microwave irradiation resulted in higher yields, shorter reaction times and cleaner reactions. The structures of the synthesized compounds were elucidated using various spectroscopic methods. Theoretical studies explained the behaviour and reactivity observed for 1-acetyl-2-naphthol with benzaldehydes considering geometries, and electron densities of the formed flavanones.
Export Options
About this article
Cite this article as:
S. Al-Bogami Abdullah, Microwave–assisted Synthesis of Chalcones, Flavanones and 2- pyrazolines: Theoretical and Experimental Study, Letters in Organic Chemistry 2012; 9 (7) . https://dx.doi.org/10.2174/157017812802139609
DOI https://dx.doi.org/10.2174/157017812802139609 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Addressing the Challenge: Current and Future Directions in Ovarian Cancer Therapy
Current Gene Therapy Novel Nucleic Acid-Based Agents: siRNAs and miRNAs
Central Nervous System Agents in Medicinal Chemistry Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins
Current Nanoscience Hydrogen Sulfide Regulates Intracellular Ca2+ Concentration in Endothelial Cells From Excised Rat Aorta
Current Pharmaceutical Biotechnology Synthesis and Pharmacological Effects of the Anti-Cancer Agent 2-Methoxyestradiol
Current Pharmaceutical Design Silencing of Disease-related Genes by Small Interfering RNAs
Current Molecular Medicine Advanced Micro-Nano-Bio Systems for Future Targeted Therapies
Current Nanoscience Remodelling of the Ca2+ Toolkit in Tumor Endothelium as a Crucial Responsible for the Resistance to Anticancer Therapies
Current Signal Transduction Therapy Patented Biomarkers of Peripheral Blood for the Early Detection of Cancer
Recent Patents on Biomarkers Collaborative and Defensive Fibroblasts in Tumor Progression and Therapy Resistance
Current Medicinal Chemistry Patent Selections:
Recent Patents on Anti-Cancer Drug Discovery Theranostics of Metastatic Prostate Cancer Applying <sup>64</sup>Cu/<sup>18</sup>F/<sup>68</sup>Ga PSMA PET-CT and <sup>177</sup>Lu Radiopharmaceuticals
Current Radiopharmaceuticals Gene Therapy Approaches for the Selective Killing of Cancer Cells
Current Pharmaceutical Design Vitamin D and Vitamin D Analogs in Cancer Treatment
Current Drug Targets Targeting Histone Deacetylases in Neuroblastoma
Current Pharmaceutical Design A Novel Trypsin and α-Chymotrypsin Inhibitor from Maclura pomifera Seeds
Letters in Drug Design & Discovery Discovery of Cationic Polymers for Non-Viral Gene Delivery Using Combinatorial Approaches
Combinatorial Chemistry & High Throughput Screening Dequalinium-Derived Nanoconstructs: A Promising Vehicle for Mitochondrial Targeting
Current Drug Delivery Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases
Current Medicinal Chemistry Network Insights into the Genes Regulated by Hepatocyte Nuclear Factor 4 in Response to Drug Induced Perturbations: A Review
Current Drug Discovery Technologies