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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A New Practical Synthesis of Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate From (S)-3-chloro-1,2-propanediol

Author(s): Chengjun Jiang and Huabin Hong

Volume 9, Issue 7, 2012

Page: [520 - 521] Pages: 2

DOI: 10.2174/157017812802139654

Price: $65

Abstract

A practical chemical synthesis of ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate((R)-CNHB) has been accomplished from (S)-3-chloro-1,2-propanediol, which is a main by-product originating from (S,S)-Salen Co(III) catalyzed by hydrolytic kinetic resolution (HKR) of epichlorohydrin. The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of the intermediate of atorvastatin.

Keywords: Atorvastatin, epichlorohydrin, by-product, (R)-(-)-4-Cyano-3-hydroxybutyrate, kinase, sterols, cholesterol, 2-propanediol, cyanide, thionyl


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