Abstract
There is growing evidence that epigenetics, the study of heritable changes in gene expression that do not involve mutations in the DNA itself, may play an essential role in autoimmune diseases (AID). In Sjogren’s syndrome (SS), a chronic AID characterized by an epithelis of the exocrine glands, epigenetic studies have focused on three mechanisms: DNA methylation and its consequences including human endogenous retrovirus (HERV) expression; microRNA expression; and protein post-translational modifications associated with autoantibody production. Although in its infancy, comprehension of the epigenetic (dys)regulation in SS may help us to understand: why SS affects predominantly middle-aged women; why genetically predisposed individuals develop SS but not others; why flare-ups occur; why treatment responses differ between patients; and why some patients develop lymphoma. From these studies will arise a better comprehension of the pathophysiology of SS as well as development of new diagnostic and prognostic biomarkers, and novel therapeutics for prevention and perhaps early intervention.
Keywords: Sjogren’s syndrome, epigenetics, DNA methylation, microRNAs, post-translational modifications, human endogenous retrovirus 1. INTRODUCTION, autoimmune diseases (AID), exocrine glands, epigenetic studies, human endogenous retrovirus (HERV), epigenetic (dys), autoantibody production, lymphoma.
Current Pharmaceutical Biotechnology
Title:Epigenetics and Sjogren’s Syndrome
Volume: 13 Issue: 10
Author(s): Christelle Le Dantec, Marie-Michele Varin, Wesley H Brooks, Jacques-Olivier Pers, Pierre Youinou and Yves Renaudineau
Affiliation:
Keywords: Sjogren’s syndrome, epigenetics, DNA methylation, microRNAs, post-translational modifications, human endogenous retrovirus 1. INTRODUCTION, autoimmune diseases (AID), exocrine glands, epigenetic studies, human endogenous retrovirus (HERV), epigenetic (dys), autoantibody production, lymphoma.
Abstract: There is growing evidence that epigenetics, the study of heritable changes in gene expression that do not involve mutations in the DNA itself, may play an essential role in autoimmune diseases (AID). In Sjogren’s syndrome (SS), a chronic AID characterized by an epithelis of the exocrine glands, epigenetic studies have focused on three mechanisms: DNA methylation and its consequences including human endogenous retrovirus (HERV) expression; microRNA expression; and protein post-translational modifications associated with autoantibody production. Although in its infancy, comprehension of the epigenetic (dys)regulation in SS may help us to understand: why SS affects predominantly middle-aged women; why genetically predisposed individuals develop SS but not others; why flare-ups occur; why treatment responses differ between patients; and why some patients develop lymphoma. From these studies will arise a better comprehension of the pathophysiology of SS as well as development of new diagnostic and prognostic biomarkers, and novel therapeutics for prevention and perhaps early intervention.
Export Options
About this article
Cite this article as:
Le Dantec Christelle, Varin Marie-Michele, H Brooks Wesley, Pers Jacques-Olivier, Youinou Pierre and Renaudineau Yves, Epigenetics and Sjogren’s Syndrome, Current Pharmaceutical Biotechnology 2012; 13 (10) . https://dx.doi.org/10.2174/138920112802273326
DOI https://dx.doi.org/10.2174/138920112802273326 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Heat Shock Proteins (HSPs) Based Anti-Cancer Vaccines
Current Molecular Medicine Editorial (Hot Topic: Medicinal Chemistry of Tumor Necrosis Factor-α Inhibitors and Related Oxidative Stress)
Current Topics in Medicinal Chemistry Editorial Review of 2014
Current Radiopharmaceuticals The Role Oxidative Stress in the Pathogenesis of Eye Diseases: Currnt Status and a Dual Role of Physical Activity
Mini-Reviews in Medicinal Chemistry Role of Neural Stem Cells in Parkinsons Disease
Current Signal Transduction Therapy Immunotherapy with Dendritic Cells as a Cancer Treatment: Perspectives and Therapeutic Potential
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Identification of Small Molecule Binding Sites within Proteins Using Phage Display Technology
Combinatorial Chemistry & High Throughput Screening NAADP Signaling Revisited
Current Topics in Medicinal Chemistry Diagnosis and Treatment of Paraneoplastic Neurological Syndromes
Current Clinical Pharmacology Recent Patents on Anti-Cancer Potential of Helenalin
Recent Patents on Anti-Cancer Drug Discovery Proteomics in the Search for Biomarkers of Animal Cancer
Current Protein & Peptide Science G Protein-Coupled Receptor Fusion Proteins in Drug Discovery
Current Pharmaceutical Design Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and New Therapeutic Perspectives in Non Small Cell Lung Cancer
Current Drug Targets Epigenetic Modifications: New Therapeutic Targets in Primary Myelofibrosis
Current Stem Cell Research & Therapy AKT: A Potential Target for Thyroid Cancer Therapy
Current Drug Targets - Immune, Endocrine & Metabolic Disorders The Multifaceted Activities of Mammalian Defensins
Current Pharmaceutical Design Regulation of Angiogenesis by Th1- and Th2-Type Cytokines
Current Pharmaceutical Design The Reciprocal Interaction: Chemotherapy and Tumor Microenvironment
Current Drug Discovery Technologies Antiangiogenesis in Myelodysplastic Syndrome
Current Cancer Drug Targets Viral Disorder or Disordered Viruses: Do Viral Proteins Possess Unique Features?
Protein & Peptide Letters