Abstract
A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40%). All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions, inexpensive reagents, high yield and simple operation.
Keywords: Tasigna, Bcr-Abl kinase inhibitor, Facile synthesis, Cu-catalyzed N-arylation, Condensation, tyrosine kinase, tyrosine kinase, Palladium, Nickel, carbonyl chlorides
Medicinal Chemistry
Title:A Novel and Facile Synthetic Approach for Tasigna
Volume: 8 Issue: 5
Author(s): Xiaoyan Pan, Wen Lu, Pengfei Li, Fang Wang, Chen Wang, Zhigang Hu and Jie Zhang
Affiliation:
Keywords: Tasigna, Bcr-Abl kinase inhibitor, Facile synthesis, Cu-catalyzed N-arylation, Condensation, tyrosine kinase, tyrosine kinase, Palladium, Nickel, carbonyl chlorides
Abstract: A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40%). All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions, inexpensive reagents, high yield and simple operation.
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Cite this article as:
Pan Xiaoyan, Lu Wen, Li Pengfei, Wang Fang, Wang Chen, Hu Zhigang and Zhang Jie, A Novel and Facile Synthetic Approach for Tasigna, Medicinal Chemistry 2012; 8 (5) . https://dx.doi.org/10.2174/157340612802084207
DOI https://dx.doi.org/10.2174/157340612802084207 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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