Palladacycles as Antimicrobial Agents

A.      -S.S.H. Elgazwy; N.      S.M. Ismail; S.      R. Atta-Allah; M.      T. Sarg; D.      H.S. Soliman; M.      Y. Zaki; M.      A. Elgamas

Abstract

This review article deals with the structure activity relationship (SAR) for a variety of palladacycles in biomedical applications. Moreover, the types of antibacterial, antifungal, antimycobacterial and antiprotozoal (antiamoebic and antitrypanosomal) activities will vary considerably from one country to another. Therefore, all efforts will be required to face such a vast diversity of problems. This study gives an up to date overview of the antibacterial, antifungal, antimycobacterial and antiprotozoal chemistry of the palladium group elements with an emphasis on the new strategies used in the development of new antibacterial agents. Methodologies for application of bulky aromatic or aliphatic nitrogen ligands, chiral organic moieties, chelates containing other donor atoms than nitrogen, and biologically active ligands in the design of agents analogous to palladacycles are presented. Therefore, the use of palladacycles in medicinal chemistry is interesting as potential application in the biological properties with less toxic drugs compounds..

Keywords: Palladacycles, organopalladium complexes, anti-bacterial, anti-fungal, anti-mycobacterial, antiprotozoal, anti-trypanosomal, antiamoebic, palladium, nitrogen