Abstract
Increased myocardial collagen accumulation is present in almost every cardiac disease and plays an important role in the reduced heart function. N-terminal and C-terminal propeptides of collagen type I and III, the two major collagen types in the heart, can be assayed in serum.These propeptides (PINP, PIIINP, PICP, ICTP) reflect collagen synthesis and degradation.
The use of these serum collagen biomarkers as prognostic or diagnostic tools is an area of active investigation. In this review article these studies will be discussed as well as the limitations of these serum biomarkers as indicators of cardiac fibrosis.
Keywords: Collagen, Biomarkers, Heart failure, Myocardial fibrosis, C-terminal propeptides, procollagen, propeptides
Cardiovascular & Hematological Disorders-Drug Targets
Title:Serum Collagen Markers and Heart Failure
Volume: 12 Issue: 1
Author(s): P. J. Lijnen, T. Maharani, N. Finahari and J. S. Prihadi
Affiliation:
Keywords: Collagen, Biomarkers, Heart failure, Myocardial fibrosis, C-terminal propeptides, procollagen, propeptides
Abstract: Increased myocardial collagen accumulation is present in almost every cardiac disease and plays an important role in the reduced heart function. N-terminal and C-terminal propeptides of collagen type I and III, the two major collagen types in the heart, can be assayed in serum.These propeptides (PINP, PIIINP, PICP, ICTP) reflect collagen synthesis and degradation.
The use of these serum collagen biomarkers as prognostic or diagnostic tools is an area of active investigation. In this review article these studies will be discussed as well as the limitations of these serum biomarkers as indicators of cardiac fibrosis.
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Cite this article as:
J. Lijnen P., Maharani T., Finahari N. and S. Prihadi J., Serum Collagen Markers and Heart Failure, Cardiovascular & Hematological Disorders-Drug Targets 2012; 12 (1) . https://dx.doi.org/10.2174/187152912801823147
DOI https://dx.doi.org/10.2174/187152912801823147 |
Print ISSN 1871-529X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4063 |
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