Abstract
Doping with erythropoietic proteins such as erythropoietin (EPO) is a serious issue in sport. There is little information on the possible ophthalmologic alterations followed by frequent EPO abuse in athletes. EPO is a potent retinal angiogenic factor and is capable of stimulating retinal angiogenesis and neovascularization in the presence of ischemia. Systemic and intravitreal EPO concentrations are highly correlated. A linkage between EPO doping and retinal proliferation is possible and further studies are warranted. Gathering and analyzing data on retinal findings from these athletes, either retrospectively or prospectively might yield preliminary information to support the safety of those athletes. Implications of this hypothesis cover other kinds of neovascularizations and angiogenesis.
Keywords: Erythropoietin, doping, retinal neovasularization, angiogenesis.
Current Drug Safety
Title:Possibility of Enhanced Risk of Retinal Angiogenesis in Athletes with Pre- Existing Retinal Situation Abusing Erythropoietin Doping: A Hypothesis
Volume: 7 Issue: 2
Author(s): Reza Rastmanesh
Affiliation:
Keywords: Erythropoietin, doping, retinal neovasularization, angiogenesis.
Abstract: Doping with erythropoietic proteins such as erythropoietin (EPO) is a serious issue in sport. There is little information on the possible ophthalmologic alterations followed by frequent EPO abuse in athletes. EPO is a potent retinal angiogenic factor and is capable of stimulating retinal angiogenesis and neovascularization in the presence of ischemia. Systemic and intravitreal EPO concentrations are highly correlated. A linkage between EPO doping and retinal proliferation is possible and further studies are warranted. Gathering and analyzing data on retinal findings from these athletes, either retrospectively or prospectively might yield preliminary information to support the safety of those athletes. Implications of this hypothesis cover other kinds of neovascularizations and angiogenesis.
Export Options
About this article
Cite this article as:
Rastmanesh Reza, Possibility of Enhanced Risk of Retinal Angiogenesis in Athletes with Pre- Existing Retinal Situation Abusing Erythropoietin Doping: A Hypothesis, Current Drug Safety 2012; 7 (2) . https://dx.doi.org/10.2174/157488612802715708
DOI https://dx.doi.org/10.2174/157488612802715708 |
Print ISSN 1574-8863 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3911 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Indicators of Cardiovascular Risk in Metabolic Syndrome: Long Term Follow-up in Italian Patients
Current Vascular Pharmacology HM74a Agonists: Will they be the New Generation of Nicotinic Acid?
Current Topics in Medicinal Chemistry Are Circulating Monocytes as Microglia Orthologues Appropriate Biomarker Targets for Neuronal Diseases? (Supplementry Table)
Central Nervous System Agents in Medicinal Chemistry The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson's Disease Model
CNS & Neurological Disorders - Drug Targets Meet Our Editorial Board Member:
Current Vascular Pharmacology 3D Printing in Modern Cardiology
Current Pharmaceutical Design Cardiovascular Disease in Systemic Lupus Erythematosus: The Role of Traditional and Lupus Related Risk Factors
Current Cardiology Reviews Adverse Drug Reactions in a Pulmonary Teaching Hospital: Incidence, Pattern, Seriousness, and Preventability
Current Drug Safety Myocardial Infarction. Pathological Relevance and Relationship with Coronary Risk Factors
Current Pharmaceutical Design Endothelial Lipase: A Key Player in HDL Metabolism Modulates Inflammation and Atherosclerotic Risk
Mini-Reviews in Medicinal Chemistry Editorial [Hot Topic : Current Practice and trends in echocardiography in Critical Care, Anesthesiology and Emergency Medicine (Guest Editor: Paulo Marcelino)]
Current Cardiology Reviews Influence of Gender on C-Reactive Protein, Fibrinogen, and Erythrocyte Sedimentation Rate in Obstructive Sleep Apnea
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Serum Interleukin-33 is a Predictor of Depression in Patients with Acute Ischemic Stroke
Current Neurovascular Research Bidirectional Nature of Cardiovascular and Kidney Disease
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The Pamela Study: Old and New Findings
Current Hypertension Reviews Editorial (Thematic Issue: Advances in Drug Discovery for the Treatment of Cancer: Many Approaches, One Goal)
Current Topics in Medicinal Chemistry Prevention of Renal Complications Induced by Non- Steroidal Anti-Inflammatory Drugs
Current Medicinal Chemistry Cardio-Vascular Risks Associated with Clozapine Treatment
Current Psychiatry Reviews Medical Image Processing Technology for Diagnosing and Treating Cancers
Recent Patents on Biomedical Engineering (Discontinued) Genetic Variations in Cytochrome P450 2C9 and 2C19: A Review
Current Pharmacogenomics and Personalized Medicine