Abstract
Vascular risk factors and atherosclerosis are critically involved in dementia development of both vascular and Alzheimer’s type. However, the exact mechanisms linking atherosclerosis and the development of Alzheimer’s disease (AD) are still unknown. As platelet activation and adhesion on vascular wall is the first step of vascular inflammation and atherosclerosis, it appears tempting to hypothesize that platelets could be the link between vascular risk factors/ atherosclerosis and AD. In recent years, much work has been accomplished to elucidate the role of platelets in AD. The present review will summarize and highlight the latest findings of this research area and provide novel insight and understanding in the association between platelet activation and AD.
Keywords: Alzheimer’s disease, platelet activation, treatment targets, vascular risk factors, atherosclerosis, hyperlipidaemia, hypertension, type 2 diabetes, MCI, serotonin
Current Vascular Pharmacology
Title:Platelet Activation in Alzheimer’s Disease: From Pathophysiology to Clinical Value
Volume: 10 Issue: 5
Author(s): Christoph Laske, Kateryna Sopova and Konstantinos Stellos
Affiliation:
Keywords: Alzheimer’s disease, platelet activation, treatment targets, vascular risk factors, atherosclerosis, hyperlipidaemia, hypertension, type 2 diabetes, MCI, serotonin
Abstract: Vascular risk factors and atherosclerosis are critically involved in dementia development of both vascular and Alzheimer’s type. However, the exact mechanisms linking atherosclerosis and the development of Alzheimer’s disease (AD) are still unknown. As platelet activation and adhesion on vascular wall is the first step of vascular inflammation and atherosclerosis, it appears tempting to hypothesize that platelets could be the link between vascular risk factors/ atherosclerosis and AD. In recent years, much work has been accomplished to elucidate the role of platelets in AD. The present review will summarize and highlight the latest findings of this research area and provide novel insight and understanding in the association between platelet activation and AD.
Export Options
About this article
Cite this article as:
Laske Christoph, Sopova Kateryna and Stellos Konstantinos, Platelet Activation in Alzheimer’s Disease: From Pathophysiology to Clinical Value, Current Vascular Pharmacology 2012; 10 (5) . https://dx.doi.org/10.2174/157016112801784657
DOI https://dx.doi.org/10.2174/157016112801784657 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
Ischemic Cardiovascular Diseases: Mechanisms, Diagnosis and Therapy
Ischemic cardiovascular disease includes myocardial infarction, coronary atherosclerotic heart disease, angina pectoris, etc., constitute the leading cause of patient mortality by preventing tissues from getting sufficient oxygen and nutrients. Ischemic heart disease, as a clinical condition, is characterized by myocardial ischemia, causing an imbalance between myocardial blood supply and demand, ...read more
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Wound Healing Effects of Curcumin: A Short Review
Current Pharmaceutical Biotechnology Inflammation, Oxidative Stress and Metabolic Syndrome: Dietary Modulation
Current Vascular Pharmacology Cardiovascular Drugs and Bone
Current Drug Safety Resveratrol: New Avenues for a Natural Compound in Neuroprotection
Current Pharmaceutical Design Clinical Evidence of Herb-Drug Interactions: A Systematic Review by the Natural Standard Research Collaboration
Current Drug Metabolism Alpha 1 Anti-Trypsin: One Protein, Many Functions
Current Molecular Medicine Iridoids Analysis by Different Analytical Techniques and its Role as Pharmacologic Agents: A Review
Current Bioactive Compounds Advances in the Management of Brain Tumors in Infants
Current Cancer Therapy Reviews The Potential Mechanisms of Exercise-induced Cognitive Protection: A Literature Review
Current Pharmaceutical Design RNA Interference as a Tool for Alzheimers Disease Therapy
Mini-Reviews in Medicinal Chemistry ADAM17 as a Therapeutic Target in Multiple Diseases
Current Pharmaceutical Design Pathophysiological Mechanisms Linking Type 2 Diabetes and Dementia: Review of Evidence from Clinical, Translational and Epidemiological Research
Current Diabetes Reviews Protective Effects of Anesthetics on Vascular Function Related to K<sup>+</sup> Channels
Current Pharmaceutical Design Synthesis, Physico-Chemical Properties and DFT Calculations of New 2-(4- Arylpiperazine-1-yl)-1-(3-ethylbenzofuran-2-yl)ethanols As Potential Antihypertensive Agents
Current Organic Chemistry Paliperidone Use in the Elderly
Current Drug Safety Pharmacological Applications of Antioxidants: Lights and Shadows
Current Drug Targets Subject Index to Volume 3
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Double-Blind, Controlled Phase II Study of a 5-HT6 Receptor Antagonist, SB-742457, in Alzheimers Disease
Current Alzheimer Research The Clinical Utility of Ambulatory Blood Pressure Monitoring (ABPM): A Review
Current Hypertension Reviews Radiopharmaceuticals in Neurological and Psychiatric Disorders
Current Clinical Pharmacology