Abstract
Tumor necrosis factor-α (TNF-α) is a major cytokine involved in the inflammatory response. Elevated TNF-α expression has been found to be associated with the development of diabetes, septic shock, tumorigenesis, cardiovascular diseases, rheumatoid arthritis and inflammatory bowel disease. In the past decade, the success of anti-TNF-α biologics has valuated the importance of the blockade of TNF-α production in the treatment of patients with various inflammatory diseases. Oxidative stress is another important element in oxidative/inflammatory responses that directly linked to oxidation of proteins, DNA and lipids. The increased oxidant levels could activate nuclear factor-kappaB (NFκ-B), signal transduction and gene expression of TNF-α, interleukin-1 (IL-1) and other pro-inflammatory cytokines. Therefore, TNF-α inhibitors with anti-oxidative stress activity may have multiple target effect that could exhibit excellent anti-inflammatory activities. The review briefly highlights the pathological roles of TNF-α and oxidative stress in inflammation, and covers those natural products as TNF-α inhibitors capable of anti-oxidative stress activity.
Keywords: TNF-α inhibitors, anti-oxidative stress, natural products, diabetes, septic shock, tumorigenesis, cardiovasculardiseases, rheumatoid arthritis, inflammatory bowel disease, anti-TNF-α biologics, TNF-α production, Oxidative stress
Current Topics in Medicinal Chemistry
Title:TNF-α Inhibitors with Anti-Oxidative Stress Activity from Natural Products
Volume: 12 Issue: 13
Author(s): Jing Li, Huibin Zhang, Wenlong Huang, Hai Qian and Ying Li
Affiliation:
Keywords: TNF-α inhibitors, anti-oxidative stress, natural products, diabetes, septic shock, tumorigenesis, cardiovasculardiseases, rheumatoid arthritis, inflammatory bowel disease, anti-TNF-α biologics, TNF-α production, Oxidative stress
Abstract: Tumor necrosis factor-α (TNF-α) is a major cytokine involved in the inflammatory response. Elevated TNF-α expression has been found to be associated with the development of diabetes, septic shock, tumorigenesis, cardiovascular diseases, rheumatoid arthritis and inflammatory bowel disease. In the past decade, the success of anti-TNF-α biologics has valuated the importance of the blockade of TNF-α production in the treatment of patients with various inflammatory diseases. Oxidative stress is another important element in oxidative/inflammatory responses that directly linked to oxidation of proteins, DNA and lipids. The increased oxidant levels could activate nuclear factor-kappaB (NFκ-B), signal transduction and gene expression of TNF-α, interleukin-1 (IL-1) and other pro-inflammatory cytokines. Therefore, TNF-α inhibitors with anti-oxidative stress activity may have multiple target effect that could exhibit excellent anti-inflammatory activities. The review briefly highlights the pathological roles of TNF-α and oxidative stress in inflammation, and covers those natural products as TNF-α inhibitors capable of anti-oxidative stress activity.
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Cite this article as:
Li Jing, Zhang Huibin, Huang Wenlong, Qian Hai and Li Ying, TNF-α Inhibitors with Anti-Oxidative Stress Activity from Natural Products, Current Topics in Medicinal Chemistry 2012; 12 (13) . https://dx.doi.org/10.2174/156802612801784434
DOI https://dx.doi.org/10.2174/156802612801784434 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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