Abstract
2-Cyanoethanethioamide (1) reacted with α,β-unsaturated ketones 2a,b to afford the corresponding 2- thioxopyridine-3-carbonitrile derivatives 6a,b. The reactivity of the latter products towards various chemical reagents was studied to yield both thieno[2,3-b]pyridines 9a-r and 3-aminothieno[2,3-b]pyridine-2-carbohydrazides 10a,b which were used in turn, to prepare N-phenylmethylenethieno[2,3-b]pyridine-2-carbohydrazides 13a,bpyrido[3`,2`:4,5]thieno[3,2- d]pyrimidinones (15a,b,16a,b) and pyrido[3`,2`:4,5]thieno[3,2-d]triazinones 17a,b. Considering the data of IR,1H NMR, mass spectra and elemental analyses the chemical structures of the newly synthesized heterocyclic compounds were elucidated.
Keywords: Pyridothienotriazinones, 2-Cyanoethanethioamide, Pyridothienopyrimidinones, N-phenylmethylenethienopyridin- 2-carbohydrazides, 2-Thioxopyridine-3-carbonitrile, antimicrobial, carbonitrile derivatives, pyridine, heterocyclic compounds, chemical reagents.
Current Bioactive Compounds
Title:Synthesis, Characterization and Antimicrobial Activity of Pyridine-3- Carbonitrile Derivatives
Volume: 8 Issue: 2
Author(s): Azza M. Abdel-Fattah, Fawzy A. Attaby, Mohamed A. A. Elneairy and Mohmoud N. M. Gouda
Affiliation:
Keywords: Pyridothienotriazinones, 2-Cyanoethanethioamide, Pyridothienopyrimidinones, N-phenylmethylenethienopyridin- 2-carbohydrazides, 2-Thioxopyridine-3-carbonitrile, antimicrobial, carbonitrile derivatives, pyridine, heterocyclic compounds, chemical reagents.
Abstract: 2-Cyanoethanethioamide (1) reacted with α,β-unsaturated ketones 2a,b to afford the corresponding 2- thioxopyridine-3-carbonitrile derivatives 6a,b. The reactivity of the latter products towards various chemical reagents was studied to yield both thieno[2,3-b]pyridines 9a-r and 3-aminothieno[2,3-b]pyridine-2-carbohydrazides 10a,b which were used in turn, to prepare N-phenylmethylenethieno[2,3-b]pyridine-2-carbohydrazides 13a,bpyrido[3`,2`:4,5]thieno[3,2- d]pyrimidinones (15a,b,16a,b) and pyrido[3`,2`:4,5]thieno[3,2-d]triazinones 17a,b. Considering the data of IR,1H NMR, mass spectra and elemental analyses the chemical structures of the newly synthesized heterocyclic compounds were elucidated.
Export Options
About this article
Cite this article as:
M. Abdel-Fattah Azza, A. Attaby Fawzy, A. A. Elneairy Mohamed and N. M. Gouda Mohmoud, Synthesis, Characterization and Antimicrobial Activity of Pyridine-3- Carbonitrile Derivatives, Current Bioactive Compounds 2012; 8 (2) . https://dx.doi.org/10.2174/157340712801784769
DOI https://dx.doi.org/10.2174/157340712801784769 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans
Drug Metabolism Letters Modulation of Ornithine Decarboxylase Activity by Phenolics Based Structurally Related Compounds Synthesized on Steroidal and Non-Steroidal Skeleton and their Radical Scavenging Action
Current Bioactive Compounds The Metabolic Fate of Apple Polyphenols in Humans
Current Nutrition & Food Science Capillary Zone Electrophoresis for Separation and Quantitative Determination of Mexiletine and its Main Phase I Metabolites
Drug Metabolism Letters Molecular Imaging of Breast Cancer: Role of RGD Peptides
Mini-Reviews in Medicinal Chemistry Nanomedicine Against Malaria
Current Medicinal Chemistry Pharmacological Benefits of Active Components of Natural Products Against Traumatic Brain Injury - A Review
Current Pharmacogenomics and Personalized Medicine Antiviral Drug Discovery Targeting to Viral Proteases
Current Pharmaceutical Design Heterocyclic Compounds as Anti-Inflammatory Agents
Current Bioactive Compounds Therapeutic Exploitation of Endogenous Anti-Inflammatory Mechanisms:Old and New Leads
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Mass Spectrometry in the Elucidation of the Glycoproteome of Bacterial Pathogens
Current Proteomics Inpatient Care of the HIV Infected Patient in the Highly Active Antiretroviral Therapy (HAART) Era
Current HIV Research The Development of Preventives and Therapeutics for Alzheimers Disease that Inhibit the Formation of β-Amyloid Fibrils (fAβ), as Well as Destabilize Preformed fAβ
Current Pharmaceutical Design IAPs as a Target for Anticancer Therapy
Current Cancer Drug Targets Cancer Stem Cells – Are Surface Markers Alone Sufficient?
Current Stem Cell Research & Therapy Natural-based Hydrogels: A Journey from Simple to Smart Networks for Medical Examination
Current Medicinal Chemistry On the Involvement of H2S in Nitroso Signaling and Other Mechanisms of H2S Action
Current Pharmaceutical Biotechnology Update of the Preclinical Situation of Anticancer Platinum Complexes: Novel Design Strategies and Innovative Analytical Approaches
Current Medicinal Chemistry Majra Honey Abrogated the Normal and Cancer Cells Proliferation Inhibition by Juniperus procera Extract and Extract/Honey Generated AgNPs
Anti-Cancer Agents in Medicinal Chemistry Playing Modular Puzzle with Adhesion/Growth-Regulatory Galectins: Design and Testing of a Hybrid to Unravel Structure-Activity Relationships
Protein & Peptide Letters