Abstract
The presence of chromosomes with diffuse centromeres (holocentric chromosomes) has been reported in several taxa since more than fifty years, but a full understanding of their origin is still lacking. Comparative and functional genomics are nowadays furnishing new data to better understand holocentric chromosome evolution thus opening new perspectives to analyse karyotype rearrangements in species with holocentric chromosomes in particular evidencing unusual common features, such as the uniform GC content and gene distribution along chromosomes.
Keywords: Holocentrism, holokinetic chromosomes, genome size, gene distribution, GC content, kinetochores, condensin, chromosome rearrangements, karyotype, cytogenetic analyses
Current Genomics
Title:Unlocking Holocentric Chromosomes: New Perspectives from Comparative and Functional Genomics?
Volume: 13 Issue: 5
Author(s): Mauro Mandrioli and Gian Carlo Manicardi
Affiliation:
Keywords: Holocentrism, holokinetic chromosomes, genome size, gene distribution, GC content, kinetochores, condensin, chromosome rearrangements, karyotype, cytogenetic analyses
Abstract: The presence of chromosomes with diffuse centromeres (holocentric chromosomes) has been reported in several taxa since more than fifty years, but a full understanding of their origin is still lacking. Comparative and functional genomics are nowadays furnishing new data to better understand holocentric chromosome evolution thus opening new perspectives to analyse karyotype rearrangements in species with holocentric chromosomes in particular evidencing unusual common features, such as the uniform GC content and gene distribution along chromosomes.
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Cite this article as:
Mandrioli Mauro and Carlo Manicardi Gian, Unlocking Holocentric Chromosomes: New Perspectives from Comparative and Functional Genomics?, Current Genomics 2012; 13 (5) . https://dx.doi.org/10.2174/138920212801619250
DOI https://dx.doi.org/10.2174/138920212801619250 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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