Abstract
High-performance liquid chromatography (HPLC) was employed in a fingerprint analysis of Radix astragali. A characteristic HPLC profile of known Radix astragali samples collected from five primary habitats in China was established by evaluating 15 samples with chemometric methods, including similarity evaluation, hierarchical cluster analysis (HCA), principal component analysis (PCA) and discriminant analysis (DA). The feasibility and advantages of employing chromatographic fingerprinting combined with chemometric methods were investigated and demonstrated in the evaluation of Radix astragali for the first time. The results showed that the chromatographic fingerprint combined with chemometric methods could efficiently distinguish Radix astragali from various areas and provide quality control in the quantitative analysis.
Keywords: Chemometric, Fingerprint, HPLC, Radix astragali, principal component analysis, discriminant analysis, nephritis, diabetes, hypertension, cirrhosis
Current Pharmaceutical Analysis
Title:Quality Control of Fingerprint of Radix Astragali by High-Performance Liquid Chromatography Coupled with Chemometric Methods
Volume: 8 Issue: 3
Author(s): Zu-fei Feng, Xiao-ming Sun, Sheng-rong Ning and Duo-long Di
Affiliation:
Keywords: Chemometric, Fingerprint, HPLC, Radix astragali, principal component analysis, discriminant analysis, nephritis, diabetes, hypertension, cirrhosis
Abstract: High-performance liquid chromatography (HPLC) was employed in a fingerprint analysis of Radix astragali. A characteristic HPLC profile of known Radix astragali samples collected from five primary habitats in China was established by evaluating 15 samples with chemometric methods, including similarity evaluation, hierarchical cluster analysis (HCA), principal component analysis (PCA) and discriminant analysis (DA). The feasibility and advantages of employing chromatographic fingerprinting combined with chemometric methods were investigated and demonstrated in the evaluation of Radix astragali for the first time. The results showed that the chromatographic fingerprint combined with chemometric methods could efficiently distinguish Radix astragali from various areas and provide quality control in the quantitative analysis.
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Cite this article as:
Feng Zu-fei, Sun Xiao-ming, Ning Sheng-rong and Di Duo-long, Quality Control of Fingerprint of Radix Astragali by High-Performance Liquid Chromatography Coupled with Chemometric Methods, Current Pharmaceutical Analysis 2012; 8 (3) . https://dx.doi.org/10.2174/157341212801619289
DOI https://dx.doi.org/10.2174/157341212801619289 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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