2,3-Disubtituted Thiazolidin-4-ones: Novel Class of Anticonvulsant Agents

Title:2,3-Disubtituted Thiazolidin-4-ones: Novel Class of Anticonvulsant Agents

Volume: 9 Issue: 7

Author(s): M. Senthilraja, V. Alagarsamy and V. Raja Solomon

Affiliation:

Keywords: Thiazolidinone, Anti-convulsant activity. Microwave-irradiation, AED, Epilepsy, mercapto acid, DCC, microwave irradiation, AED, anti-inflammatory, cholerectic, anti-HIV, MCRs, Thomas Hoover melting point, FT-NMR spectrometer

Abstract: A new series of 2,3-disubstituted thiazolidin-4-ones were synthesized from the appropriate amines, substituted aldehyde, and mercaptoacetic acid in the presence of DCC in anhydrous THF by microwave irradiation. The title compounds were investigated for their anticonvulsant activity. Among the test compounds, compound 2-(4- bromophenyl)-2-methylthiazolidin-4-one-3-isonicotinamide (8) emerged as most active compound of the series and it is moderately more potent than the reference standard diazepam.

Cite this article as:

Senthilraja M., Alagarsamy V. and Raja Solomon V., 2,3-Disubtituted Thiazolidin-4-ones: Novel Class of Anticonvulsant Agents, Letters in Drug Design & Discovery 2012; 9 (7) . https://dx.doi.org/10.2174/157018012801319517