Abstract
Lipinski’s rule of five is well received throughout the world and widely used as one of the basic filters to screen ligands for their druggability. In this direction, we have studied 148 biologically active natural products which are available as drugs. Physicochemical parameters such as molecular weight, logP, hydrogen bond donors, hydrogen bond acceptors, number of aromatic rings, molar refractivity and Gibbs free energy were calculated. Statistical results reveal that, they do fall under the Lipinski’s rule of 5 (RO5). The illustration about need for the study, methods followed and results obtained are reported here.
Keywords: Lipinski’s rule of five, Physicochemical parameters, Druggability, Druglikliness, Natural products, Gibbs free energy, logP, Physicochemical parameters, pharmaceutical industry, combinatorial chemistry, high throughput screening techniques, ADME (absorption, distribution, metabolism, excretion), Lipinski’s RO5, semisynthetic modification, clogP & logP
Letters in Drug Design & Discovery
Title:Quantitative Measurement of Some Physico-Chemical Parameters for the Medicinally Useful Natural Products
Volume: 9 Issue: 7
Author(s): Koyel Kar, Aditya Sethi, D. Archana, S. Vasavi, P. Maheswari, P. Niranjini, L. Vimalacharitha, W. Prathyusha, V. Sai Thanuja, K. Sreejana Reddy, G. Rohith, Amnish Kumar, A. G. Damodar and B. R. Prashantha Kumar
Affiliation:
Keywords: Lipinski’s rule of five, Physicochemical parameters, Druggability, Druglikliness, Natural products, Gibbs free energy, logP, Physicochemical parameters, pharmaceutical industry, combinatorial chemistry, high throughput screening techniques, ADME (absorption, distribution, metabolism, excretion), Lipinski’s RO5, semisynthetic modification, clogP & logP
Abstract: Lipinski’s rule of five is well received throughout the world and widely used as one of the basic filters to screen ligands for their druggability. In this direction, we have studied 148 biologically active natural products which are available as drugs. Physicochemical parameters such as molecular weight, logP, hydrogen bond donors, hydrogen bond acceptors, number of aromatic rings, molar refractivity and Gibbs free energy were calculated. Statistical results reveal that, they do fall under the Lipinski’s rule of 5 (RO5). The illustration about need for the study, methods followed and results obtained are reported here.
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Kar Koyel, Sethi Aditya, Archana D., Vasavi S., Maheswari P., Niranjini P., Vimalacharitha L., Prathyusha W., Sai Thanuja V., Sreejana Reddy K., Rohith G., Kumar Amnish, G. Damodar A. and R. Prashantha Kumar B., Quantitative Measurement of Some Physico-Chemical Parameters for the Medicinally Useful Natural Products, Letters in Drug Design & Discovery 2012; 9 (7) . https://dx.doi.org/10.2174/157018012801319427
DOI https://dx.doi.org/10.2174/157018012801319427 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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