Central Nervous System Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

ISSN (Print): 1871-5249
ISSN (Online): 1875-6166

Volume 22 , Issues 3, 2022

This journal supports open access

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Editorial Board


cnsamc Editor-in-Chief 4667 Ramon Cacabelos International Center of Neuroscience and Genomic Medicine EuroEspes Biomedical Research Center Corunna Spain

Dr. Ramón Cacabelos is Professor of Genomic Medicine and President of the EuroEspes Biomedical Research Center, Corunna, Spain. He received his M.D. from Oviedo University, Ph.D. from Santiago University, and D.M.Sci. (Psychiatry) from Osaka University Medical School, Osaka, Japan. After a decade at the Department of Psychiatry in Osaka, he returned to Spain and focused his research activity on the genomics and pharmacogenomics of neurodegenerative disorders. He has published over 600 papers and 24 books, is Editor-in-Chief of the first World Guide for Drug Use and Pharmacogenomics, and is President of the World Association of Genomic Medicine.

rcacabelos@euroespes.com
Associate Editors 4669 Sergey O. Bachurin Physiologically Active Compounds Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS) Moscow Russia

Sergey Bachurin received the Ph.D. degree in 1980. Since 1981 he works in the Institute of Physiologically Active Compounds Russian Academy of Sciences (RAS). Since 2006 he is a Director of the Institute. In 2003 he was elected as a member of RAS. His research activity related to the discovery of novel agents for neurodegenerative diseases treatment. Bachurin was invited scholar in University of California, San Francisco and in Tufts University, Boston. He is Russian national representative in IUPAC and Council member of European Federation of Medicinal Chemistry. He is the author of more than 200 and about 40 patents.

bachurin@ipac.ac.ru
4668 Gian L. Mariottini Department of Earth University of Genova Genova Italy

MSc and MD, fellow of the Provincial Medical and Odontological Register (Genova), of the Italian Society of Experimental Biology and of the Solidarity, Projects and Resources for Africa University Board. He worked at the G.Gaslini Pediatric Hospital of Genova carrying out research on neuroblastoma; at present he deals with ecotoxicology, toxicology, and natural extract activity on cultured cells at the University of Genova (Department of Earth, Environment and Life Sciences). He participated in national and international research projects and working groups, is Associate Editor, Editorial Board member and reviewer for international scientific journals, Guest Editor for special issues of journals and books, and author of 152 publications, including 9 teaching books.

gian.luigi.mariottini@unige.it gian.luigi.mariotttini@unige.it
4670 John L. Neumeyer Medicinal Chemistry Program McLean Hospital Belmont MA United States

Dr. Neumeyer received his BS in Chemistry from Columbia University and PhD in Medicinal Chemistry from the University of Wisconsin, Madison, WI. He joined the faculty of Northeastern University as Professor of Medicinal Chemistry and was appointed Matthews Distinguished Professor. Dr. Neumeyer was a cofounder of Research Biochemicals, Inc. Dr. Neumeyer has had a long career in medicinal chemistry as evidenced in more than 400 scientific publications. He is currently the director of the Medicinal Chemistry Laboratory at McLean Hospital, Harvard Medical School. Dr. Neumeyer was inducted into the American Chemical Society’s Division of Medicinal Chemistry Hall of Fame in 2008.

jneumeyer@mclean.harvard.edu
6911 Dora Zelena Institute of Experimental Medicine Hungarian Academy of Sciences Gvadányi Hungary zelena.dora@koki.mta.hu
Regional Editors NORTH AMERICA 4673 Sayyed H. Fatemi Department of Psychiatry, Division of Neuroscience Research University of Minnesota Medical School Minneapolis MN United States

M. Fatemi received his PhD in Electrical Engineering from Purdue University. Currently, he is a Professor of Biomedical Engineering at the Mayo Clinic College of Medicine, and a member of Mayo Clinic Cancer Center, Cancer Imaging Program, and the Center for Translational Science Activities. In addition, he is a faculty member of the Biomedical Informatics and Computational Biology graduate program at the University of Minnesota Rochester. His current research areas include ultrasonic methods for tissue viscoelasticity and nonlinear elasticity estimation for applications in cancer imaging and bladder function evaluation. He is an elected Fellow of IEEE, AIMBE, ASA, and AIUM. He is the recipient of the IEEE-UFFC Distinguished Lecturer award for 2016-2017.

fatem002@umn.edu
4671 Sadayuki Hashioka Department of Psychiatry, Faculty of Medicine Shimane University Izumo Japan

Dr. Sadayuki Hashioka is an Associate Professor of Department of Psychiatry, Shimane University, Izumo, Japan. He received his MD in 1998 from the Faculty of Medicine, University of Miyazaki, Japan. After four years of clinical work as a psychiatrist, he received his PhD in 2006 from the Department of Neuropsychiatry, Kyushu University, Fukuoka, Japan. He subsequently obtained five-year training as a postdoctoral fellow under Drs. Edith and Patrick McGeer at the Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada.

hashioka@med.shimane-u.ac.jp
Asia 4672 Dennis Q. Wang Department of Neurology Zhujiang Hospital of Southern Medical University Guangzhou China

Prof. D.Q. Wang is Vice-Head at the Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University. He obtained his Ph. D from National University of Singapore and he is Postdoctoral Fellow at Stanford University and NHMRC from Australia. He is regular a member of Asia Pacific Society for Neurochemistry, NSFC of China Grant and Committee Member of Chinese Parkinson‘s Disease & Movement Disorders Society, “Frontiers in Cellular Neuroscience”. He was awarded as Young Investigator in 2010 from Ministry of Education. He obtained 26 National Grants and has published 45 SCI papers.

denniswq@yahoo.com
Section Editor 8676 Neural network in learning and memory Simone Battaglia Centre for Studies and Research in Cognitive Neuroscience University of Bologna Cesena Italy

Simone Battaglia is currently a Senior Postdoctoral Researcher in the Department of Psychology, University of Turin, Research Fellow and Psychologist at the Centre for Studies and Research in Cognitive Neuroscience, Department of Psychology, University of Bologna (Italy).
His research interests focus on neural, physiological, and behavioral correlates of fear memories in humans. In particular, he is interested in the neural systems that allow to reduce or even erase fear from memories. These processes involve interaction between brain areas, such as the prefrontal cortex, amygdala, and hippocampus. However, the role of the prefrontal cortex is still unclear in humans. Therefore, his goal is to better understand the functional role of the prefrontal cortex - in humans - in both the acquisition/extinction and reconsolidation of fear memories. To this end, his research in the neuroscience field includes the use of non-invasive brain stimulation (i.e., TMS and tDCS), and the recording of different physiological measures such as EEG, SCR, HRV, and EMG. During his PhD and Postdoctoral Fellowship, he contributed to extending the current literature concerning the description and the understanding of emotional memories, and in particular, the fear of learning in humans.
His findings allowed developments in understanding the neurobiological basis of human fear conditioning both in healthy and brain-damaged individuals. In particular, such evidence might provide key insights and a deeper understanding of critical issues concerning the acquisition, the extinction and, the reconsolidation of fear memories in humans.

4674 Dale Ding Department of Neurological Surgery University of Louisville School of Medicine Louisville KY United States

Dale Ding is an Assistant Professor of Neurosurgery at the University Of Louisville School Of Medicine. He obtained his degree from Duke University School of Medicine. He completed residency in Neurological Surgery at the University of Virginia, research fellowships in vascular biology and cerebrovascular disease at the University of Virginia, a clinical fellowship in Cerebrovascular and Skull Base Surgery at Auckland City Hospital, and an ACGME/CAST-accredited fellowship in Endovascular Surgical Neuroradiology at Barrow Neurological Institute. He is a diplomat of the American Board of Neurological Surgeons. His translational and clinical research efforts focus on hemorrhagic and ischemic cerebrovascular disorders.

Cerebrovascular Disease daleding1234@gmail.com
8782 Artificial Intelligence Application to Neuroscience Hyunsu Lee Orcid Department of Medical Informatics School of Medicine Keimyung University Dalseo-gu South Korea

Hyunsu Lee is currently working as an assistant professor in the Department of Medical Informatics at Keimyung University, School of Medicine. His current research interests are medical and neuroscientific applications of artificial intelligence. Among AI fields, he is particularly interested in reinforcement learning algorithms. Reinforcement learning draws interest as a convergence field of various fields, such as psychology, neuroscience, and artificial intelligence.

Frontiers Section Editor 4695 Yuri N. Utkin Shemyakin & Ovchinnikov Instituteof Bioorganic Chemistry RussianAcademy of Sciences (IBCH RAS) Moscow Russia

Yuri N. Utkin received his PhD in Bioorganic Chemistry from the Shemyakin Institute of Bioorganic Chemistry of the Academy of Sciences of the USSR. After earning the PhD degree he continued his career at the same Institute (now the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS), receiving a DSc degree in 1996 and being promoted to Professor in 2006. Prof. Utkin is the head of the laboratory of molecular toxinology. He has published more than 150 scientific publications in peer reviewed journals. Professor Utkin is a member of the European Society for Neurochemistry, the International Society on Toxinology, and the American Society for Biochemistry and Molecular Biology.

Bioorganic Chemistry utkin@mx.ibch.ru
Editorial Board Members 4685 Laura Betti Department of Pharmacy University of Pisa Pisa Toscana Italy

Dr. Laura Betti, obtained a PhD in Neurobiology and Clinic of Affective Disorders from the University of Pisa, Italy. In the same University, she also received her Speciality in Clinical Biochemistry and her Biological Degree. Currently Dr. Betti is a Researcher in Biochemistry at the Department of Pharmacy of the University of Pisa. She has over 20 years of the experience in the research of proteins and their role in transduction mechanisms in physiological and pathological conditions. She has published 100 publications in the fields of biochemistry, as well as clinical biochemistry and neurosciences with particular reference to neurotransmitters and receptor systems.

betti@farm.unipi.it laura.betti@unipi.it
4681 Daniele Bottai Department of Health Science University of Milan Milan Italy

Dr. Bottai has obtained Ph.D. in Neuroscience from the University of Pisa, Italy and McGill University, Montreal, Quebec, Canada. He is presently working as an Assistant Professor in Pharmacology, Department of Science Health University of Milan. He is Ordinary member of the Italian Society of Pharmacology. He is in Collaboration with International Scientific Journals such as Reviewer of The Lancet, Journal of Neurochemistry, Associated Editor: Frontiers in Stem Cells Treatments and Associated Editor: Frontiers in Cell and Developmental Biology. He has contributed more than 30 publications, having citations around 946.

daniele.bottai@unimi.it
4676 Carmen V. González Department of Pharmacology University of Santiago de Compostela Lugo Spain

Dr. C. Vale is an Associate Professor in University of Santiago de Compostela, Faculty of Veterinary, Lugo. She completed her Degree in Pharmacy, University of Santiago de Compostela. She further obtained PhD in Pharmacy, Neurochemistry, University of Barcelona (1998): neurotoxicity of organic pollutants. She also did the Postdoctoral at the Center for Neural Science, New York University. Supervisor: Dan H. Sanes. Study of synaptic plasticity in the auditory system (1998-2000). Associate Professor, Faculty of Medicine, University of Castilla-La Mancha (2000-2004). 2004-Present: Study of marine toxins in neuronal systems, Universidade de Santiago de Compostela.

mdelcarmen.vale@usc.es
4678 Vittorio Gentile Department of Precision Medicine University of Campania "Luigi Vanvitelli" Naples Italy

Dr. Gentile (Naples, Italy) is a recognized expert in the transglutaminase research area and has a strong background in the molecular biology and biochemical aspects of the transglutaminase (TG) enzymes expression, activity and function. His work has been focused on the tissue TG (TG2) characterization in normal and pathological cellular events (cell growth and differentiation, adhesion, apoptosis, neurodegeneration) by molecular biology, immunological and biochemical studies. Currently, he works as associate professor at the University of Campania “Luigi Vanvitelli”.

vittorio.gentile@unicampania.it vittorio.gentile@unina2.it
4683 Roberta Galeazzi Department of Life and Environmental Science (DISVA) Marche Polythecnic University Ancona Italy

Dr. Roberta Galeazzi obtained her deegree in chemistry (1992) frfom the University of Bologna cum laude and worked as researcher since January 1993 at the Polytechnic Marche University, where she is assistant professor (SSD CHIM/06) of the Department of Life and Environmental Sciences (DISVA). Dr. Galeazzi’s main research activity concerns molecular docking and molecular dynamics profiling of novel active compounds or natural ligands to their receptors with the aim of rationalizing the molecular basis of biological processes fundamental for the transduction of specific biochemical and physiological effects. She is co-author of 80 papers published in international peer-review journals and has attended congresses with oral and poster presentations.

r.galeazzi@univpm.it r.galeazzi@staff.univpm.it
4687 Christopher Hulme College of Pharmacy University of Arizona Oro Valley AZ United States

Dr. Hulme received a doctorate degree (D.Phil) in Chemistry from the University of Oxford, England. He currently is a full Professor at the University of Arizona and Director of the Medicinal Chemistry BIO5 Drug Discovery Core. Prior to moving to academia, Dr. Hulme built and managed several high-throughput medicinal chemistry organizations in industry (1994 – 2007, Sanofi, Amgen, Lilly), spanning a multitude of therapeutic areas including Neurodegeneration through the targeting of CNS kinases. Dr. Hulme has > 175 publications, book chapters, and patents.

hulme@pharmacy.arizona.edu
6913 Andrew G. Horti Department of Radiology and Radiological Science Johns Hopkins University Baltimore Maryland United States

Dr. Horti is an Associate Professor in the Department of Radiology and Radiological Science at Johns Hopkins University, Maryland. He has devoted his career to the development of short-lived radiotracers for PET, in particular radioligands for imaging of cerebral receptors and enzymes in human subjects. His scientific results have been published in various peer-reviewed journals, invited reviews supported by NIH, private foundations and pharmaceutical industry. He also holds appointments on editorial boards for several scientific journals. He is an active member of the Society of Nuclear Medicine and Molecular Imaging and he has organized research sessions and continuing education sessions for a number of SNMMI meetings.

ahorti1@jhmi.edu
4675 Amar N. Kar Department of Biology University of South Carolina Columbia SC United States

Dr. Amar N Kar received his PhD in Neuroscience from the Northwestern University in 2010. He obtained M.S. (Biomedical Science) and B.S. (Microbiology) from the University of Delhi, India in 2002 and 2000 respectively. Currently, he is a Research Assistant Professor at the Univ. of SC, Jeff Twiss Lab. He is a highly motivated scientist with extensive experience in cellular and molecular neuroscience focusing on mitochondrial function and neurodegeneration. His research expertise includes in vitro models of neurodegeneration using primary, embryonic stem cell and chemically induced stem cell-derived cells, transcriptomics, proteomics, and translatomics, cell biological aspect (biochemistry, cell signalling, mitochondrial activity and microscopy) and in vivo central and peripheral nervous system injury models (utilization of animal models to evaluate small molecules as potential therapeutics). Besides, he has published several articles in distinguished journals.

karan2@mailbox.sc.edu
4682 Rosaria Meccariello Orcid Department of Motor Sciences and Wellness University of Naples Parthenope Naples Italy

Dr. Meccariello obtained her Degree in Biology at the University of Naples Federico, Italy in 1997. She further got Ph.D. in Comparative Endocrinology at the University of Padova, Italy in 2004. She is presently serving as an Associate Professor of Biology at the Department of Movement and Wellness Sciences at Parthenope University of Naples, Italy. Her field of expertise is in Biology of reproduction, reproductive endocrinology, spermatogenesis, sperm quality, hypothalamus - pituitary - gonad (HPG) axis, endocannabinoids, endocrine disruptor chemicals, central and local regulation of testicular activity in vertebrates. She has contributed more than 80 publications, having citations around 1495.

​0000-0003-2174-1118 meccariello@uniparthenope.it rosaria.meccariello@uniparthenope.it
4688 Barbara Malawska Department of Physicochemical Drug Analysis University Collegium Medicum Kraków Poland mfmalaws@cyf-kr.edu.pl 4680 Beatrice Macchi Department of System Medicine University of Rome Tor Vergata Rome Italy

Dr. Beatrice Macchi is Assistant Professor in the Pharmacology Section of Department of Systems Medicine at University of Rome Tor Vergata, Italy. She is also Principal Investigator of the laboratory of molecular antiviral research in the Department of System Medicine, at University of Rome Tor Vergata. Her skills and expertise mainly lie in the subject areas of PCR, Cell Culture, Cancer Biology, Flow Cytometry, Proteins, Biotechnology, Infection, Apoptosis, Immunology of Infectious Diseases, HIV, Cancer Research, etc. Dr. Macchi, as an author/co-author, has published more than 90 articles in various journals, having over 1,200 total citations.

macchi@med.uniroma2.it
4689 Ilya Okun ChemDiv, Inc. San Diego CA United States iokun@chemdiv.com 4690 Keykavous Parang Professor of Medicinal Chemistry and Pharmacology Chapman University Orange CA United States

Dr. Parang is Associate Dean of Research, Graduate Studies and Global Affairs and a Full Professor of Medicinal Chemistry and Pharmacology at Chapman University School of Pharmacy in Irvine, California. He earned a Pharm.D degree from Tehran University of Medical Sciences in 1989. He received his Ph.D. in Medicinal Chemistry from the Faculty of Pharmacy at University of Alberta in 1997, followed by a postdoctoral study in the fields of carbohydrate chemistry and solid-phase organic synthesis in Department of Chemistry. He pursued additional postdoctoral studies at Rockefeller University in New York and Johns Hopkins University in Baltimore in Bioorganic chemistry. He is an author of 170 peer-reviewed publications, 8 patents, and more than 140 meeting.

parang@chapman.edu
4691 Charles Ramassamy Neurobiology INRS-Institute Armand-Frappier Montreal QC Canada

Prof. Charles Ramassamy has successively obtained his DEA (Diploma of Advanced Studies) in Molecular and Cellular Pharmacology at Paris V University, and a PhD in Neuroscience, option neuropharmacology, at the University of Rouen in France. After completing a postdoctoral fellowship at McGill University, at the Douglas Mental Health University Institute Research Center in the laboratory of Dr. Judes Poirier, he became professor of pharmacology at the Université du Québec à Trois-Rivières, then professor at the INRS-Institut Armand-Frappier. He is also an associate professor at Laval University and a regular researcher at the Institute on Nutrition and Functional Foods, Laval University.

charles.ramassamy@iaf.inrs.ca
4684 Federico Sesti Department of Neuroscience & Cell Biology Robert Wood Johnson Medical Schoo Piscataway NJ United States

Dr. Federico Sesti is a Professor of Neuroscience and Cell Biology, Rutgers University. He received his Laurea and Ph.D. in Physics from the University of Genova, Italy. He was a postdoctoral fellow in the laboratory of Benjamin Kaupp, Institut für Biologische Informationsverarbeitung, Forschungszentrum Jülich (Germany) and in the laboratory of Steve Goldstein at Yale University (USA). He is a Fulbrigh Scholar, and member of several scientific societies. He serves in the editorial board of several journals and in international, federal and private funding agencies.

sestife@rwjms.rutgers.edu
4679 Rakesh K. Tiwari School of Pharmacy Chapman University Irvine CA United States

Dr. Rakesh Kumar Tiwari is currently an Assistant Professor of Biopharmaceutical and Biomedical Sciences. He joined CUSP in September 2013. He received his Ph.D. (2006) in Organic Chemistry from Dr. B.R. Ambedker Center for Biomedical Research, University of Delhi. In 2007, Dr. Tiwari’s strong interest to conduct research in the area of application of chemistry in biology led him to pursue his postdoctoral research at University of Rhode Island. His postdoctoral work resulted in the synthesis of several peptide as neuroprotective agents, nanomaterials, kinase inhibitors as anticancer compounds, and many cell-penetrating peptide.

tiwari@chapman.edu
Associate Editorial Board Members 6912 Majid Asadi-Shekaari Neuroscience Research Center, Neuropharmacology Institute Kerman University of Medical Sciences Kerman Iran

Dr. Asadi-Shekaari has more than 12 years experience in Electron Microscopy and is the author more than 50 scientific publications. Following a Ph.D. in Histology he took up a position as an academic staff of Kerman Neuroscience Research Center (KNRC). Dr. Asadi-Shekaari is a member of Japan Neuroscience Society (JNS) (Membership ID 1606152769), International Society of Neurochemistry (ISN) (Membership ID 23578), Iranian Neuroscience Society and International Brain Research Organization (IBRO). He is currently head of Electron and Histology laboratories of KNRC. His research area consists of experimental models of Cerebral Ischemia, Epilepsy and Alzheimer. He has served as a reviewer of Oncotarget, Biomedicine and Pharmacotherapy, Clinical and Experimental Physiology and Pharmacology (CEPP), Human and Experimental Toxicology (HET), Neural Regeneration Research (NRR), Iranian Journal of Pathology (IJP), and Current Topics in Neuroscience.

majidasa@gmail.com majidasadi@kmu.ac.ir
8618 Emrah Caylak Department of Biochemistry Cankiri Karatekin University Cankiri Turkey

Emrah Caylak, Ph.D., is a biochemist and lecturer in the faculty of Health Sciences at Karatekin University, in Cankiri, TURKEY. He is a medical researcher and teacher in the Biochemistry Department. He graduated from the Department of Biochemistry and Clinical Biochemistry, School of Medicine, Firat University, Elazig, TURKEY.

4692 Maryam Noorbakhshnia Department of Plant and Animal Biology University of Isfahan Isfahan Iran

Dr. Maryam Noorbakhshnia is currently an Assistant Professor at the University of Isfahan (Research and teaching different physiology courses to bachelor and master students). She did Ph.D. from Tehran University in 2007 (Major: physiology of the nervous system). Before that, she did her MSc from Tehran University in the year 2000 (Major: physiology of the nervous system).

mnoorbakhshnia@yahoo.com
Executive Guest Editor 4693 Vittorio Gentile Department of Precision Medicine University of Campania "Luigi Vanvitelli" Naples Italy

Dr. Gentile (Naples, Italy) is a recognized expert in the transglutaminase research area and has a strong background in the molecular biology and biochemical aspects of the transglutaminase (TG) enzymes expression, activity and function. His work has been focused on the tissue TG (TG2) characterization in normal and pathological cellular events (cell growth and differentiation, adhesion, apoptosis, neurodegeneration) by molecular biology, immunological and biochemical studies. Currently, he works as associate professor at the University of Campania “Luigi Vanvitelli”.

vittorio.gentile@unicampania.it vittorio.gentile@unina2.it
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