The Ultimate Frontier of Knowledge: the Mysterious Genomes and the Gene Expression and Regulation in the Upstream of Biological Information Flow

Abstract

DNA sequencing is just a tool that we can employ to study biological phenomena. It can be useful for us to review some biological background before we discuss how to use the tool. It will help us to understand what subjects in the biological field DNA sequencing can be applied to and how to apply sequencing technologies in the study. Before we discuss the applications of DNA sequencing, Let’s review some molecular biology, starting from the structure and organization of information molecules at the molecular level.

Keywords: Alternative splicing, Central dogma, Chromatin, DNA packaging, Epigenetic modifications, Euchromatin, Gene, Genome, Heterochromatin, MicroRNA, Nucleosome, Transcription factors.