Frontiers in Clinical Drug Research: HIV

Volume: 1

New Developments for Anti-HIV Treatment

Author(s): Liã Bárbara Arruda and Jorge Casseb

Pp: 58-66 (9)

Doi: 10.2174/9781608058969114010004

* (Excluding Mailing and Handling)


Viral suppression is necessary to control the evolution of drug resistance, reduce the chronic immune activation, which is associated with morbidity and mortality in HIV-infected patients, reducing viral transmission, including transmission of drug resistance. In general, the proportion of viremic patients who achieved suppression increases with the number of pharmacokinetically active antiretroviral therapy regimen in. Guidelines to antiretroviral treatment today recommend the use of at least three antiretroviral agents (ART) selected from different drug classes, which may include inhibitors of reverse transcriptase nucleoside (NRTI), reverse transcriptase inhibitors Non-nucleoside inhibitors (NNRTIs) inhibitors protease (PI's), entry inhibitors and integrase inhibitors. There is regarding when to start therapy, what drugs should be used, how to manage the risk of toxicity and how to improve adherence to treatment. The impact of co-morbidities conditions in the selection of drugs and the risk of emergence of resistant viruses must also be considered as deciding factors. Thus, this review covers the last advances in ART, specifically focusing integrase inhibitors and entry inhibitors.

Keywords: Entry inhibitors, HIV-1, HAART, integrase inhibitors.

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