Serum creatinine is one of the most common blood tests. In this chapter, we review some historical data regarding creatinine. Different methodologies to measure creatinine in blood and urine are described. We also discuss the physiological reason for its use as a glomerular filtration rate marker. Moreover, analytical and physiological limitations will be described and discussed. The use of the creatinine clearance is also discussed.
Keywords: Creatinine, glomerular filtration rate, interferences