Molecular Oncology: Principles and Recent Advances

IV. Example 1: Hepatocellular Carcinoma

Author(s): Pablo Muriel

Pp: 44-47 (4)

Doi: 10.2174/978160805016111201010044

* (Excluding Mailing and Handling)

Abstract

Primary liver cancer is the sixth most common cancer in the world and the third cause of death by cancer due to its bad prognosis. Most primary liver cancers are Hepatocellular Carcinomas (HCC). The major risk factors for HCC are chronic liver diseases (especially cirrhosis) including hepatitis B and C, alcoholic liver disease, non-alcoholic steatohepatitis, estrogens, and well documented environmental preventable risk factors, among others. Rho, hepatocyte growth factor, and metalloproteinases are associated with metastasis and death from HCC.


Keywords: Cancer, fibrosis, necrosis, cirrhosis NF-κB, alcoholic liver disease, metalloproteinases, HBV, HCV, aflatoxins, hemochromatosis.

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